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Inhaling this gas may help severe corona patients
Swedish researchers have found that inhaling nitrogen nitrogen can help treat severe Covid-19 patients who suffer from severe respiratory failure.
However, this is a treatment that is not free of risks and side effects
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Monday, 12 October 2020, 00:34
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Severe corona patients who come to the hospital and experience severe breathing difficulties are treated by doctors in a number of protocols that have already been shown to be beneficial over the past few months - anti-inflammatory drugs such as Ramadosibir or steroid drugs such as Dexamethasone and the like.
However, a recent study in Sweden suggests another therapeutic direction that may be helpful: inhaling nitric oxide gas (Nitric Oxide or NO for short).
Although so far the effect of the gas has only been tested under laboratory conditions, the researchers believe that oxygen nitrogen has the potential to fight Covid-19 disease.
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"We hope that oxygen nitrogen inhalation can be an effective therapeutic avenue, until there is a vaccine," said Aka Lundskvist, who led the study, in a press release. Lecturer in the Department of Medical Biochemistry and Microbiology at Uppsala University in Sweden.
"An effective therapeutic route until the vaccine arrives."
Corona patient resuscitated in intensive care unit at Seattle Hospital, USA (Photo: Reuters)
Oxygen nitrogen is known for its ability to dilate blocked blood vessels, thereby improving blood flow to various organs.
When the gas is inhaled in low doses, it can also reduce inflammation and improve lung oxidation in patients with severe respiratory failure - a common complication in Covid-19 patients.
Although we are currently reporting it in the context of a new study, treatment with oxygen nitrogen is not new in medicine.
In 1999 the US Food and Drug Administration (FDA) approved the use of gas to revitalize preterm infants with severe respiratory failure.
However, past studies emphasize and warn that the success, efficacy and especially safety of this gas treatment without concomitant complications largely depends on the use of low doses (20 ppm), adherence to an accurate treatment protocol, and close supervision.
Antiviral gas
Swedish researchers believe that the therapeutic benefits of this gas are largely due to its versatility.
Nitric oxide is used to treat a wide variety of bacteria, fungi and viruses.
In fact, the current study from Uppsala University takes a hit on another study, which dealt with the SARS-CoV virus that caused the outbreak of the SARS epidemic in 2003 in 29 countries.
The same virus is very genetically similar to the current SARS-CoV-2 virus that causes Covid-19, so is quite likely to compare the two.
In both studies - the current one and the one that preceded it - the researchers found that nitrogen oxide treatment prevented the virus from replicating, thus proving that it has antiviral properties.
Inhalation of the gas prevented the virus from replicating itself in the cells.
Inhalation Mask (Illustration: Shutterstock)
In the new experiment at Uppsala University, the researchers used organic compounds called SNAP (S-nitroso-N-acetylpenicillamine) that are able to release oxygen nitrogen, to test how they affect virus-infected cells inside test tubes.
In addition, the researchers also examined the effect of another type of compound (without the ability to release oxygen nitrogen) on the virus, under the same conditions.
The SNAP compounds were those that showed therapeutic potential in the experiment.
These compounds, sometimes referred to as "nitrogen nitrogen donors," have been used to treat a variety of health problems, including heart attacks and obstructive heart failure.
In the United States, too, a number of studies are currently underway aimed at determining whether oxygen nitrogen can be used as a therapeutic channel in Covid-19 and they are expected to be completed and publish their conclusions over the coming year.
Last July, researchers from George Washington University School of Medicine and Health Sciences released an interim review of data collected between 1993 and 2020 that examines the therapeutic effects of oxygen nitrogen on respiratory diseases.
The researchers concluded that using gas may make the health care system easier because it would save the need to connect some patients to respirators.
For the past twenty years oxygen nitrogen has been approved for use in resuscitation of preterm infants with severe respiratory failure.
Peg receives oxygen (illustration: shutterstock)
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Oxygen nitrogen also appears to be beneficial in the treatment of pregnant women.
Last August, 6 pregnant women who contracted Covid-19 and were hospitalized in Massachusetts General Hospital received a high dose of oxygen nitrogen (160-200 ppm) by inhalation.
The women received the treatment twice a day.
An article published in the journal Obstetrics and Gynecology states that 5 of the women recovered from their serious illness within 4 weeks.
As for side effects, oxygen nitrogen treatment is not without them.
One scientific review of gas treatment, published in 2016, stated that "inhalation of oxygen nitrogen causes a temporary improvement in the oxidation of blood and organs, but it does not reduce mortality and may also be harmful as it appears to cause kidney damage."
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