In Fossombrone the Irish wins, Roglic attacks, Ganna leaves. The day after Davide Bais' solo victory at Campo Imperatore, the Giro d'Italia celebrates the feat of the young Irishman Ben Healy.

The time trial in Romagna, which closes the first week of the race, puts the leadership up for grabs but can also give a clearer physiognomy to the classification. Opened with the news of the withdrawal of Filippo Ganna, who tested positive for Covid (the same reason had stopped Nicola Conci and Giovanni Aleotti)