Joe Biden appoints Jack Markell, former governor of Delaware, ambassador to Italy. Markell is currently the US representative to the OECD.

Lewis Eisenberg, appointed by Donald Trump, completed his term on January 17, 2021. Since then the United States has been represented by chargé d'affaires Shawn Crowley. If confirmed by the Senate, the diplomatic headquarters of Rome will thus have an ambassador again after more than two years, even if the technical timing of confirmation to Congress will probably not allow him to manage the expected visit of Prime Minister Giorgia Meloni.