Manchester City and Real Madrid won the first leg of the round of 16 away, beating Copenhagen 3-1 and Red Bull Leipzig 1-1 respectively. It took the trophy holders only 10 minutes to take the lead at the Parken Stadium with a goal from De Bruyne.
Real without Jude Bellingham and with many absences in defense (Antonio Ruediger, David Alaba and EderMilitao) managed to beat Red Bull thanks to a goal at the start of the second half by Brahim Diaz.