Osteogenesis imperfecta is a rare condition characterized by bone fragility and osteopenia. Symptoms appear mainly in early childhood, but can also be discovered in adulthood in more attenuated forms.
In 90% of cases, "glass bone disease" is due to a mutation in one of the two genes that encode type I collagen. Bisphosphonate infusions can be performed during 3 days of hospitalization every 4 months, for a maximum of 4 years. It is considered hereditary by the High Authority of Health.