The Gallery of Royal Collections brings together masterpieces by Velázquez, Caravaggio or Goya from the royal collections. Most of the 650 works in the permanent exhibition were previously not accessible and gathered dust in storerooms or wings of palaces and monasteries closed to the public.

A second floor is dedicated to the Bourbon dynasty, of the current King Felipe VI. A third level will host temporary exhibitions but also an "immersive" cube where 360° images of dozens of "royal sites" across Spain, from which the exhibits are derived, will be projected.