Simone Inzaghi's men will have to defend the 1-0 from the first leg at San Siro. The Nerazzurri have not reached the quarter-finals since the 2009-'10 seasons (in which they achieved the Treble) and 2010-'11, when instead they were eliminated at the hands of Schalke 04.
The last victory in Spain in fact came in October 2004 (5-1 against Valencia) and that success is followed by six defeats and three draws against Iberian teams.