12 actors who were controversially replaced: from Johnny Depp, to Rachel Weisz, to Ryan Gosling. Most of the time, it was the studios who decided to change the performers.
But there were cases in which the actors themselves refused to return to the characters. No actor or actress has been spared from experiencing being "eliminated" from the "second parts" throughout their career. Whether by someone else's decision or your own, these 12 artists were not part of the game.