Bayer Leverkusen in the quarter-finals against West Ham. The Premier League club had eliminated Freiburg.

Bayer only secured a 3-2 victory in the second leg of the round of 16 with two goals in stoppage time against Karabakh Agdam from Azerbaijan. The quarter-final will be played on April 11th and 18th. Should the winner of the Europa League's predecessor competition, the UEFA Cup, from 1988 make it to the semi-finals, AC Milan and AS Roma would be the opponent.