Francisco Cerúndolo (20th seed) plays Karen Khachanov (15th) for a place in the round of 16 of the tournament that is played on cement in Miami Gardens. The Argentine has just beaten the Austrian Sebastian Ofner 7-6 (2), 6-7 (2) and 6-1 in the second round.

It is the third time that the Argentine and the Russian meet on the ATP circuit. The tournament in Miami suits the oldest of the Cerúdolo brothers very well.