Mogami safflower is a flower with circulatory properties chosen by Shiseido for its new treatment. Flower is used both for dyeing (silk but also in makeup) and for its medicinal benefits.

Flower's antioxidant and especially circulatory powers give rise to a new patented and highly concentrated active ingredient, SafflowerRed. The Supreme Concentrated Cream is intended for mature skin after 60 years. The formula of the Concentrated Supreme Cream is also based on ReNeuraRED Technology, a complex inspired by neuroscience.