Ancient DNA from pre-Hispanic populations in Mesoamerica reveals a genetic continuity that indicates their adaptation after several centuries of megadroughts. This resistance and ability to adapt draws attention to the serious political crisis that caused later in the Mayan civilization great droughts, which had also led to the collapse of empires such as the Hittite in Antiquity.

The current indigenous groups of the country maintain similarities in their DNA with that of the ancient inhabitants. The genetic diversity of pre- Hispanic peoples shows extensive continuity for at least the last 2,300 years and still survives in Mexico today.