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Can this emergency treatment prevent post-exposure infection?
Scientists in the UK are injecting two types of antibodies into people who have been exposed to a verified patient, hoping the treatment will prevent them from developing Covid-19 disease.
"The shot skips the stage where your body has to do the hard work"
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Corona
covid-19
Vaccine for corona
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Sunday, 27 December 2020, 10:09
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Ten people received antibody treatment as an emergency response after being exposed and were in close contact with a verified corona patient within 8 days.
Patients were given an antibody injection as part of a new emergency protocol test, hoping the antibody treatment would prove effective in preventing post-exposure infection, and could serve as a means of protecting those who had not yet been vaccinated and especially those who could not be vaccinated for various corona vaccines.
The trial is taking place at University College London University Hospital under the auspices of UK government health services, and aims to test whether an injection containing two types of antibodies can prevent a person exposed to the corona virus from developing Covid-19, or at least prevent it from developing a serious illness.
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To the full article
Although mass vaccination campaigns have been launched around the world, with the aim of vaccinating as large a percentage of the population as possible, it will take several weeks for the person who received the vaccine to be effectively protected.
However, the current antibody therapy, developed by the pharmaceutical company Astra-Zenica, should be able to neutralize the virus immediately, and then provide the patient with active protection against the virus for an entire year.
The experimental treatment may be particularly useful for caregivers and nursing home workers.
90-year-old receives Pfizer vaccine in Scotland, UK (Photo: Reuters)
The experimental treatment may be particularly useful for medical staff, nursing staff and caregivers, who are at high risk for exposure to the virus, as well as for susceptible populations who cannot receive the vaccine.
In addition, scientists claim, the antibody treatment may prevent spotty outbreaks of the virus following isolated cases, under conditions that can flare up quickly such as in dormitories.
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The study is led by Dr. Catherine Holyhan, who hopes to recruit 1,000 volunteers for the study. She and her colleagues are especially looking for volunteers from areas where the chances of exposure are particularly high, such as hospitals and dormitories. Those who want to apply will have to prove that a person in their immediate environment is verified. .
"Antibody donation"
The injection is actually an "antibody contribution" - "it skips the stage where your body has to do the hard work" (to produce them), explained Dr. Holyhan. "We know that combining these antibodies can neutralize the virus, so we hope to prove that giving this treatment actually injection provides immediate protection against the development of disease Covid-19 people have been exposed to the virus - that is, at it's too late to give them the vaccine, "she said.
Dr. Houlihan added that this technique is already used in the treatment of exposure to other viruses - like Rabies, and cases of chickenpox exposure in pregnant women.
Hopefully proving that the antibody injection provides immediate protection against the development of a disease as well as future protection from infection for a year.
Preparations for the arrival of vaccines at a hospital in Indiana, USA (Photo: Reuters)
Another experiment currently underway at University College in the same antibody injection seeks to test whether it can be used as a preventative measure even before exposure to a verified patient (similar to a vaccine).
This treatment channel may be particularly useful for treating people with immunodeficiency or undergoing immunosuppressive therapies, such as cancer patients receiving chemotherapy, for example.
Much more expensive than a vaccine
Dr. Nicky Longley, an infectious disease specialist who oversees antibody testing even before exposure to the virus said the treatment was tested on experimenters with medical conditions such as cancer and HIV, which could impair the immune system's ability to respond to the vaccine. "We want to reassure people for whom the vaccine is Not an option we can provide them with equally effective alternative protection. ”
However, Dr. Holyhan emphasized that antibody injection is not offered as a competing alternative to the vaccine, in part because it is a much more expensive option than a vaccine.
Preliminary results of the two British trials currently underway in the antibody injection are expected to be published in the spring.
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