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It turns out that this common drug can kill cancer cells - Walla! health

2021-01-06T06:01:43.326Z

Researchers have found that the drug Imodium - known primarily as an antidiarrheal drug - can cause the death of aggressive brain cancer cells. How does this happen and is it relevant for other cancers? Here are all the details



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It turns out that this common drug can kill cancer cells

Researchers have found that the drug Imodium - known primarily as an antidiarrheal drug - can cause the death of aggressive brain cancer cells.

How does this happen and is it relevant for other cancers?

Here are all the details

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  • cancer

  • Diarrhea

Walla!

health

Wednesday, 06 January 2021, 06:35

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A common and well-known drug.

A man taking a pill (Photo: ShutterStock)

A very common remedy for diarrhea may be an effective treatment against an aggressive type of brain cancer, according to a new study published in the journal Autophagy.



Past research has shown that the drug loperamide, better known as imodium or stop-it, causes the death of glioblastoma cells, but the mechanism that causes it remains unknown.

In the present study, the researchers found the pathway by which the drug causes cells to self-destruct.

This discovery may turn the drug into a therapeutic tool, one that could be used to develop new ways to fight the deadly form of brain cancer.

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The pathway in which the drug causes cells to self-destruct is called autophagy - which means "self-eating".

Autophagy constantly occurs in the body as a necessary means of removing damaged or malignant cells.

However, through a variety of mechanisms, cancer can sometimes evade this system, and grow rapidly out of control.

It is assumed that if researchers succeed in causing utopia to exist in specific cancer cells, the disease can be stopped.

"Our experiments show that utopia can support the treatment of glioblastoma-type brain tumors," said the study's lead author, Dr. Sabard van Wick.

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Dr. Van Wick and his team, from the Institute for Pediatric Cancer Research in Pediatrics at Goethe University, found that the drug raises the expression of the ATF4 gene associated with autophagy. Stopping production of ATF4, the loperamide did not cause cell destruction, suggesting that the drug requires action of ATF4 to kill cancer cells.After further investigation, the researchers found that by re-regulating ATF4, loperamide appears to cause stress markers that eventually Of thing to the death of the cancer cells.

"New and Fascinating Options for Treating Other Diseases."

Doctor looks at brain scans (Photo: ShutterStock)

In addition to ATF4, the study also highlighted other receptors involved in the loperamide-induced autophagy pathway, which can be extremely useful in the fight against glioblastoma.

Dr. Van Wick also believes that this mechanism may be applicable for the treatment of neurological diseases and other serious. "Our findings open up new and fascinating possibilities for the treatment of other diseases, such as neurological disorders or dementia, as well as other types of tumors," said the researcher.



There is need for research Before the drug can be validated as a treatment option for glioblastoma, it will also be necessary to find a method that will allow the loperamide to cross the blood-brain barrier and reach tumors, but this is still significant news. Researchers now hope to further understand the loperamide route and identify more drug candidates Similar.

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Source: walla

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