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Biontech develops promising vaccine against MS - first tests successful

2021-01-13T22:10:53.733Z


MS is an autoimmune disease that can cause visual disturbances or even paralysis. There is no cure - but maybe a vaccination in the foreseeable future.


MS is an autoimmune disease that can cause visual disturbances or even paralysis.

There is no cure - but maybe a vaccination in the foreseeable future.

  • In MS, the immune system wrongly classifies the sheaths of nerve pathways as foreign bodies.

    As a result, they are attacked and destroyed by the body's own defenses, which results in typical MS symptoms such as visual disturbances, insecurity when walking or symptoms of paralysis.

  • So far, there are no drugs with which doctors could treat the causal disease of multiple sclerosis.

    However, early onset MS therapy * can significantly slow the progression of the disease. 

  • A new vaccine is now raising completely new hopes: In animal experiments on mice

    , it was possible to prevent MS disease in vaccinated animals, and in animals with the onset of MS, the vaccination stopped the progression of the disease

    .

    Find out when the vaccine should be tested on humans here.

More and more people are suffering from the nervous disease MS.

Within the last 40 years, the number of patients has doubled, as the Ärztezeitung reported.

A trend seen in some autoimmune diseases.

The immune system is wrongly directed against the body's own tissue, which in the case of MS immensely restricts mobility and can even lead to paralysis.

So

far, there is no cure,

but the current news about a vaccine from the Mainz company Biontech and the University of Mainz is raising hope in MS patients

.

Although the preparation was only tested in animal experiments, the results are promising: According to Biontech, the vaccine was able to prevent MS from developing in mice.

Animals with MS were also vaccinated, with the result that the disease did not worsen.

Even body functions that were already disturbed, such as those with difficulty walking, regressed after the vaccination

.

MS vaccination: study in humans possible in two years at the earliest

The vaccine suppresses the overreaction of the immune system that is typical for the disease, which also makes it interesting for the treatment of other autoimmune diseases, according to the Pharmazeutische Zeitung (PZ).

The MS vaccination developed by Christina Krienke's translational oncology team at the University Medical Center in Mainz (TRON) together with the Mainz company Biontech is based, like the Biontech corona vaccination, on messenger RNA (mRNA).

The goal of the MS vaccination is to stimulate the body to produce the self-antigens that cause disease, which in turn should lead to tolerance

.

According to the PZ, the vaccine is designed in such a way that, despite the increased production of self-antigens, there should not be an overreaction of the immune system.

As the SWR-Wissenschaftsredaktion reported, the first clinical studies on humans are to follow, but this will be the case in two years at the earliest.

The MS vaccine must first be tested on human cells in the laboratory.

(jg)

 *

Merkur.de is part of the nationwide Ippen-Digital editorial network.

To the study

More sources: https://www.aerztezeitung.de/Medizin/Warum-es-heute-so-viele-MS-Kranke-gibt-225639.html

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Source: merkur

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