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The surprising link between fecal bacteria and corona

It has been known for years that the bacteria that live in our body - the microbiome - have a direct effect on our health, so researchers have decided to test whether they also affect the corona.

They tested fecal samples from 100 corona patients, which is what they found

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• germs

• Good bacteria

• Microbiome

• I'm just asking

• Corona

Dr. Idan Goren

Friday, 22 January 2021, 07:44

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The term microbiome includes all the bacteria, viruses and fungi that live in the human body, and there are quite a few of them.

The central location where most of these organisms reside is within our digestive system.

Until the middle of the 20th century, microbiology, the same industry that studied bacteria, viruses and fungi, concentrated mainly on their clinical aspects as pathogens, but thanks to the improvement in molecular biology and our ability to identify the genes of all those organisms, there was significant progress in understanding the field.

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One of the goals of the human microbiome project, as well as of many other studies that have been done and are being done in the field, also in Israel, is to characterize those bacteria and analyze their role in human health and disease.

The number of genes in all the bacteria in a single person's microbiome is 200 times greater than the number of genes in the entire human genome.

Why is the microbiome important to our health?

Bacteria can help the body digest nutrients that our body is unable to break down.

Certain bacteria also produce for the body vitamins such as vitamin K which is very important for the coagulation ability of the blood, vitamin B, and even nutrients that nourish the cells of the digestive system, various substances that can affect the health of our digestive system, immune system and probably also protect us from disease Certain and from other bacteria that can cause disease.

The condition can be defined as the interaction between the body and the creatures living in it.

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What diseases do gut bacteria affect?

Diversity and richness of the bacterial population in the gut has been linked to good health, while a decrease in the variety of bacteria has been linked to diseases, such as inflammatory bowel disease.

In recent years, many studies have examined the link between gut bacteria and chronic diseases outside the digestive tract as well, such as obesity, diabetes, asthma, tumors and liver disease.

Also affect our weight.

Fat woman (Photo: ShutterStock)

In addition, studies from recent years have also found an association with cardiovascular disease, gallstones, kidney disease, various autoimmune diseases and even neurological diseases.

In some situations, such as obesity in mice, it has been found that the replacement of intestinal bacteria is so significant that it has succeeded in turning a lean mouse into fat and vice versa.

Although many studies have found a causal link between the mix of gut bacteria and disease, only in some cases a causal link has been found.

And what is the relationship between gut bacteria and COVID-19 severity?

A new study published by a group of researchers from Hong Kong at the beginning of Prof. Siu Ann's first reports an interesting link between a decrease in certain species of bacteria in the gut and inflammatory activity in the bodies of people who have had COVID-19.

The researchers identified that in people who had a serious illness, high levels of inflammatory cytokines and inflammatory markers associated with a significant inflammatory response in the body were found - unsurprisingly.

What the study revisits is the link between these conditions and the bacterial microbiome in those patients.

The researchers examined blood and fecal samples from 100 verified patients at two Hong Kong hospitals from February to March 2020, and for a third of them continued to collect fecal samples over the course of a month from the diagnosis of SARS-CoV-2.

Most patients were in mild to moderate condition, 5 percent with severe disease and 3 percent were defined as critically ill.

Significant change in the microbiome.

Treatment of Corona patient (Photo: Reuters)

Compared to people without COVID-19, patients were identified with certain bacterial populations that were not present in healthy people.

These bacteria were also found in verified patients who did not receive any medication (since medications may themselves affect the gut bacteria).

The main changes found include a decrease in bacterial richness and diversity, a decrease in specific populations of bacteria that are considered beneficial, and an increase in pro-inflammatory bacteria.

Among the validated patients, the researchers were able to identify bacterial populations that were correlated with the severity of the disease, i.e., the pattern of intestinal bacteria was a mirror image of the severity of inflammation in the body.

Another interesting finding was that a small group of patients showed an imbalance (dysbiosis) of intestinal bacteria in samples taken a month after the infection.

This finding may explain why some COVID-19 symptoms, such as fatigue, shortness of breath and joint pain, tend to last for weeks and even months after infection.

These results add a very topical dimension to the study of gut bacteria and the link between gut bacteria and an immune response.

The inflammatory response is the cause associated with multisystem injury and mortality from the coronavirus, so the thought that gut bacteria may take part in regulating the severity of the disease is fascinating.

It is possible, and in the future, researchers will be able to identify a profile of intestinal bacteria associated with a lower or higher-than-average risk of COVID-19 similar to what is known today, for example, in the context of diabetes and obesity.

In addition, these findings are in addition to previous studies that found that obesity and diabetes, which are associated with unhealthy eating habits and affect the mix of gut bacteria, have been found to increase the risk of infection and COVID-19 complications.

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