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Why might the British mutation be more lethal?
As if the war on the virus that paralyzed the world was not enough, new variants came and preyed on the cards.
We already know that the British breed is more contagious, but now it seems that this is not the only problem with it.
Dr. Idan Goren explains why
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Corona
Corona virus
The British mutation
The South African mutation
I'm just asking
Dr. Idan Goren
Friday, 29 January 2021, 07:56
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The news that new strains of the corona virus are spreading in Israel and around the world and may be more deadly, raises great concern in Israel and around the world, and rightly so.
Over the past month and a half, it seems that the eruption of the corona in Israel has entered a new and more challenging phase.
The impression is that the age of the seriously ill is declining and more people without risk factors or background diseases are developing a serious illness.
And we are not alone.
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In mid-January, two separate studies were presented in the UK linking data on people infected with the virus in the community with mortality data, and found a 30 percent increase in the risk of death from the new strain.
These data point to the fact that there is a real possibility that the new variant that came from the UK is more contagious and deadly than it was in the past.
What exactly has changed?
In the context of the British mutation, the researchers estimate that it is a group of mutations that has made the virus more contagious, but further research is needed to confirm this.
A specific mutation that has been identified may increase the virus' ability to bind more strongly to human cells, which can significantly increase its rate of infection, but not only that.
If the virus is more contagious - it may also, for example, be able to spread more quickly and efficiently between lung cells, which may also increase the severity of the disease and its complications.
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How does this affect COVID-19 patients?
At this stage, apart from the increase in the number of severe patients, there is still no evidence that COVID-19 treatments work less well.
Treatments such as dexamethasone, for example, are not specific to this or that variant of the virus.
The same is true for respiratory support.
Works against any variant.
Dexmethasone (Photo: Reuters)
And how is the effectiveness of the vaccine affected?
As for vaccines, a preliminary study conducted this month in the UK and the Netherlands found that vaccines may maintain their ability to protect against the new variants as well, as Pfizer and Moderna estimates.
In a recently published study, which has not yet been peer-reviewed, it appears that Modern's vaccine is likely to protect against the British and South African variants.
A Pfizer study published last month found that their vaccine (the one distributed in Israel) also apparently protects against the British variant.
These findings add to the growing body of experiments that have tested the blood-antibody efficacy of vaccines against the virus against new variants.
So is there room for optimism?
Careful.
Despite the encouraging impression, Moderna's study contains a clear warning sign: Although the disease-fighting antibodies appear to work against the South African variant, their effectiveness has diminished over time.
These findings prompted the company, as well as Pfizer, to start designing a new potential vaccine that could be added to the two current vaccines if necessary, and that would soon be tested in human trials.
Modern and Pfizer will also simultaneously test whether adding a third dose of the current vaccine can elicit an effective immune response against the South African variant.
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