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The British mutation continues to change and this is very worrying
A small change in the threatening British mutation could change all the power relations of the vaccines against the virus and concerned researchers.
What does this mean and what are the possible dangers facing us?
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mutation
The British mutation
Corona
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Wednesday, 03 February 2021, 10:02
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As if we were missing trouble, it now turns out that the British version of the corona virus has undergone another mutation.
Surprisingly, the additional mutation - known as E484K - is identical to that found in the Brazilian and South African versions of SARS-CoV-2, but appears to have been created separately in the UK.
A report released this week by the UK Public Health (PHE) stated that the E484K mutation of the spike protein, found in the Brazilian and South African versions, had been identified in at least 11 samples sequenced in the UK and that "preliminary information indicates more than one infection event".
In other words, the new mutation appears to have been created separately from the existing mutation version of the virus in the UK.
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Why might the British mutation be more lethal?
To the full article
Mutations are a natural part of the life cycle of the virus, and during the plague there were thousands of SARS-CoV-2 variants that underwent subtle mutations, most of which were ineffective or harmless.
However, the British version is problematic because it includes a prominent mutation - known as the N501Y mutation - on its spike protein, the part of the virus used to enter host cells and the target site of most vaccines.
The Brazilian and South African versions carry the N501Y mutation along with E484K on the spike protein.
It now appears that a small number of variations in the UK have also absorbed the E484K mutation.
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The mutation of the mutation
The E484K mutation has now been identified in a small proportion of virus-carrying sequences that define the British version.
"This indicates that the British version is now independently acquiring the change in E484K," explained Dr. Jonathan Stoy, of the Retro-Virus Interactions Laboratory at the Francis Creek Institute.
The virus continues to develop.
Corona virus (Photo: Giphy, KAUST; Ivan Viola)
This is particularly worrying because E484K is considered to be the major mutation affecting vaccine efficacy.
For example, a recent trial of the Novavax vaccine found it to be 85.6 percent effective against the British version, but compared to the rapidly spreading South African version, its effectiveness is only about 60 percent.
It may sound surprising that the mutation also appeared separately in the British version, but researchers say it is not entirely unexpected.
"The mutation may be due to recombination with one of the South African / Brazilian viruses, which may have infected the same cell - as we see in different influenza viruses - but this is more rare in viruses," said Dr Julian Tang, a clinical virologist at the University of Leicester in the UK. "So it may be more by choice / natural / parallel development among the human population as the virus adapts to this new host - viruses can only develop through continuous replication." It is
too early to say how this effect will affect the wider outbreak or even the UK response to its outbreak. However, the observation is based on growing evidence that despite the most stringent measures to delay or prevent its spread, the virus is evolving around the world and leading to a large number of victims.
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