Vector vaccine as a trigger for thrombosis? Doctors suspect transport virus as the cause

In contrast to mRNA vaccinations, the Astrazeneca and Johnson & Johnson vaccines showed increased levels of thrombosis.

Researchers claim to have found an explanation.

After a corona vaccination, there are usually only harmless symptoms - which are actually a good sign.

If the body reacts with mild symptoms of the disease, this proves that the immune system is producing antibodies against the disease.

But in very rare cases serious complications are also possible.

For example, if a person who has been vaccinated is allergic to a component of the vaccination.

Cases of thrombosis after a corona vaccination have also been reported

- especially after vaccinations with so-called vector vaccines.

With this technology, harmless genetic material of the coronavirus (called transport virus or vector) is smuggled into human cells in order to stimulate the immune system to produce antibodies against the coronavirus.

Vector vaccines include Astrazeneca and Johnson & Johnson products.

You can find out more about the mode of action of mRNA and vector vaccines here.

The Paul Ehrlich Institute (PEI), the Federal Institute for Vaccines and Biomedical Medicines, had reported 59 cases of sinus and cerebral vein thrombosis after the first vaccination with the vector vaccine from Astrazeneca by April 15, according to the

Ärzteblatt

. This resulted in a short vaccination freeze in Germany. The Astrazeneca product is currently being vaccinated again, as the advantages of the vaccination outweigh the risks, according to the classification of responsible authorities such as the Federal Ministry of Health.

A similar picture emerged with the vaccination with the Johnson & Johnson product in the USA

. This was also no longer vaccinated after six cases of cerebral vein thrombosis became known after the vaccination.

More about the mode of action and side effects of the Johnson & Johnson vaccination.

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Medical staff vaccinates people on May 8, 2021 during a special vaccination campaign in the Ditib Central Mosque in the Ehrenfeld district of Cologne.

The excess doses are Astrazeneca and Johnson & Johnson vaccines - both vector vaccines.

© Henning Kaiser / dpa

Why are thromboses very rare after vaccination with vector vaccine?

"It could be the vector"

These incidents raise the question of whether vector vaccines carry a higher risk of thrombosis than mRNA vaccinations such as those from the manufacturers Biontech and Moderna. Immunologist Andreas Greinacher from the University of Greifswald and his team tried to answer this question. In a previously published study, they came to the

conclusion that an autoimmune reaction to the so-called platelet factor-4 could be the cause of the thrombosis

. This is a surface protein that is involved in the immune response. The protein is able to cluster around immune cells with certain receptors and thus strengthen a local immune response, like

Deutsche Welle

as a foreign broadcaster of the Federal Republic of Germany.

The phenomenon is known among medical professionals as "heparin-induced thrombocytopenia" (HIT) - an autoimmune reaction to the administration of the anticoagulant heparin, which reduces the number of blood platelets.

But in the case of corona vector vaccinations, the platelet factor-4 does not react to heparin, but to something else, the Berlin doctor Klamroth is

quoted

by

Deutsche Welle

as saying: “

It could be the vector.

It could be something from the spike protein

.

It could be something in the general immune response that has to be linked to platelet factor-4, ”speculates Klamroth.

More research is needed to find the real cause.

(jg)

More sources: https://www.aerzteblatt.de/nachrichten/123186/

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List of rubric lists: © Henning Kaiser