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Breakthrough: Israeli researchers discover how to inhibit cancer cell development
Researchers at Ben-Gurion University of the Negev have been able to crack the cell-to-cell communication mechanism and activate proteins that kill cancer cells without harming healthy cells.
"The discovery of this mechanism is a significant breakthrough"
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cancer
breast cancer
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Thursday, 10 June 2021, 08:23 Updated: 08:33
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Researchers at Ben-Gurion University of the Negev have discovered that proteins that kill cancer cells can be inhibited through a new communication mechanism between cells.
The breakthrough will delay the development of cancer cells and allow a delay in the deterioration of diseases such as juvenile diabetes, breast cancer and lung cancer.
In recent years, we have been working in the laboratory of Dr. Eid Agbaria, a researcher in the Department of Life Sciences at Ben-Gurion University of the Negev, in order to understand how the various cell organelles in the human body communicate with each other in disease states. Do not function as expected.
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To the full article
Recently, Dr. Agbaria discovered a new control mechanism in one of the cell's organelles called the endoplasmic reticulum. On the connections with other cells through receiving and transmitting new messages.The network is also important in the context of viral diseases such as COVID-19 as there are many viruses that use this organelle as an entry point into the cell and are also secreted out of it, on their way to infect other cells.
The researchers were able to differentiate the specific protein that only affects cancer cells and not healthy cells.
Cancer cells, illustration (Photo: ShutterStock)
The control mechanism found by Dr. Agbaria is responsible for the indoplasmic network proteins leaving their natural place for the cytosol (another class in the cell) and from there binding to proteins, whose function is to kill cells, and inhibit their activity. the brain of the most aggressive.
after investigating the matter, realized the research group that the learning mechanism can assist them in finding a solution to the delay in tumor cells that can develop and harm, but there is still a problem because if you delay protein normal cells they affect the development of normal cells are not cancerous. after several experiments In yeast and later in the laboratory, the study group was able to differentiate and inhibit only the specific protein released into cancer cells using protein 53-B. This breakthrough means that researchers could inhibit the development of cancer cells without harming normal cells.
The communication mechanism of the proteins studied is particularly relevant to a particularly aggressive type of brain cancer.
Chemotherapy (Photo: ShutterStock)
"The discovery of the mechanism is a significant breakthrough that will help us study and understand biological results that have remained unexplained for more than three decades. Thanks to the discovery, we propose new and very focused strategies aimed at inhibiting cancer cell development while inhibiting the new "Without compromising their original function (which also occurs in normal cells)," explained Dr. Agbaria. The study was published in PNAS, one of the world's leading scientific journals.
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The significance of the discovery was realized by Dr. Agbaria's research group after seven years of researching cancer cells.
At first we thought we were wrong, so why would a particular protein go to a place that does not belong to it?
So we did several experiments until we realized we were up to something new.
"Understanding the meaning of communication and movement between cells allowed us to reach a mechanism for cell inhibition," says Dr. Agbaria.
Now, researchers are continuing to study dozens of different proteins that come out of cancer cells and are trying to figure out how the research findings can be projected onto a specific treatment for cancer patients.
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