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High consumption of peanuts may help cancer cell proliferation - research
Do you eat peanut butter, bamba or just snack on peanuts every day?
A new study has found that * excessive * eating of peanuts may promote cancer cell development in patients.
Here are all the details that are important to know
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Thursday, 12 August 2021, 07:00 Updated: 07:07
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Potential bad news for those who really like peanuts, or alternatively are addicted to bamba or peanut butter: According to a recent study, it appears that peanuts may be associated with an increased risk of cancer spreading.
The University of Liverpool study, published in the journal Carcinogenesis, found that in cancer patients, a protein present in peanuts - peanut agglutinin (PNA) - can improve the secretion of the two molecules known to promote the spread of cancer.
These molecules are cytokines, small proteins that are important in cell signaling and the body's immune system response.
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IL-6 and MCP-1, as they are commonly known, promote metastasis of cancer and improve the expression of adhesion molecules on the surface of endothelial cells, which line the walls of blood vessels.
These endothelial cells become more attractive to the tumor cells in the bloodstream, thus increasing the number of interactions between the two - leading to a greater risk of the spread of metastases in the body.
"Although more research is needed, the current study suggests that very frequent consumption of peanuts by cancer patients may increase the risk of metastatic spread," said Professor Lu-gang Yu of the University of Liverpool, the study's author.
Oops.
Peanuts and Peanut Butter (Photo: ShutterStock)
Peanut agglutinin is a protein that quickly enters the bloodstream after eating peanuts because it is resistant to cooking and digestion.
It makes up only about 0.15 percent of the weight of peanuts.
While the present study details the induction of cytokines by the interaction of PNA with endothelial cells, an earlier study by the same authors found an alternative way in which it might promote tumor proliferation.
PNA interacts with a protein found on the surface of the tumor in the bloodstream, causing changes in the protein that make the cancer cells more sticky and more likely to attach to blood vessels.
This stickiness also allows the cancer cells to cluster together, prolonging their survival as they circulate in the bloodstream.
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Stop for a moment
Before you completely shake off peanuts and go out into your new life without Bamba, it should be noted that previous studies have observed significant peanut agglutinin concentrations in the blood only after consuming a particularly large amount of peanuts. How big is it? 250 g. The recommended daily allowance is 28 grams, which is equivalent to a small handful. "It may be that 'normal' peanut consumption that results in lower peanut agglutinin concentrations is not harmful," Hugh said.
It is also worth noting that no correlation was found with cancer mortality - in fact, one large study in the US reported that "there is no significant effect of peanut consumption on cancer mortality", while the rest reported that "peanut consumption has no significant effect on prognosis in men with prostate cancer Based, "according to Hugh.
Much more research is needed so that we can understand the effect of eating peanuts on the spread of tumors in cancer patients.
"However, the possibility remains that PNA distribution, at least at the relatively high levels found shortly after eating a large dose of peanuts, may have a significant biological effect on tumor cells, with the potential to increase the risk of metastasis," Hugh said. Peanut consumption is large or very frequent. "
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