Gonzalo herman
08/24/2021 12:22 PM
Clarín.com
Society
Updated 08/24/2021 12:49 PM
The
multisystemic inflammatory syndrome in children
(SIM-C) began to be studied as one of the
sequelae caused by COVID-19
.
It is a serious disease for which, a year and a half after the coronavirus pandemic began, an important step was taken in order to find a
treatment
, after the discovery of its
possible origin.
The American Academy of Pediatrics (AAP), in the face of parental fear, tried to assuage fear by saying that
very few children become seriously ill from
the virus that causes COVID-19.
Additionally, most of the children who have been diagnosed with C-SIM
recovered after receiving medical care.
However, concerns remain and research is progressing to find a treatment for this condition, which can cause
gastrointestinal, skin and mucosal
disorders
and, in the most severe cases, cardiac
disorders
in the form of myocarditis.
Symptoms appear after passing the coronavirus, around four weeks after
acute infection
, at which point the PCR test may even appear negative.
The syndrome is an
inflammatory response of the body
.
Coronavirus in boys.
One of the sequelae can be an inflammatory syndrome.
An investigation discovered the origin of the pathology.
A working group of the World Health Organization (WHO) reported that SIM-C occurs in
1 in 100,000 children
- in the United States they have reported more than 2,600 cases since the pandemic began.
The figures, they added, remain stable.
An investigation published in Nature Communications disclosed that
an important clue
was found
on the origin and development of this syndrome: the depletion of T cells due to permanent exposure to pathogens in patients with SIM-C, may be one of the factors driving this syndrome. disease.
This phenomenon suggests that "an increase in both NK (natural killer) cells and depleted CD8 + T cells could
improve symptoms of inflammatory disease,"
said Noam Beckmann, of the Mount Sinai Hospital Research Center of New York (United States) and co-author of the work.
This study found nine key regulators of this network, which are known to have associations with the functionality of NK cells and depleted CD8 + T cells.
"One of these regulators, TBX21, is a promising therapeutic clue, because it serves as the master coordinator of the transition of CD8 + T cells from efficient to depleted," said the researcher.
Although
an autoimmune factor
was suggested
as the underlying cause
since the first cases of this syndrome appeared
, the specific genes, pathways and specific cell types remained unknown.
Through this new finding, the researchers took an important step, by sequencing RNA from blood samples, by providing the field with new avenues of exploration involving complex networks and sub-networks of genes that they constructed from pediatric SIM-C cases.
The most significant implications of these gene networks involved the suppression of two types of immune cells: natural killer (NK) cells and CD8 + T cells.
"Previous research has shown that when CD8 + T cells are persistently exposed to pathogens, they
enter a state of 'depletion'
, resulting in a loss of their efficacy and ability to proliferate."
It is thus considered that CD8 + T cells, in particular, are in this state of exhaustion, which could
weaken the immune response to the inflammatory reaction.
Case in Argentina
In mid-July, an 8-year-old girl died after several days of
hospitalization
in the
Evita hospital
in Lanús, where she had to be admitted for the "multisystemic inflammation syndrome", after contracting coronavirus.
The girl, identified as Julieta, suffered from the disease with mild symptoms and a few days later she had a skin rash, which was treated with a cream by her family pediatrician;
However, she began to present a picture compatible with gastroenteritis for which she was taken to the Lanús hospital.
SC
Look also
An 8-year-old girl died of Covid after 9 days in hospital: her parents ask for vaccination for the boys
When the spots on the skin of the boys can derive from a Covid picture
