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Covid-19: a booster dose with a different vaccine seems more effective, believes the European regulator


In some combinations, using a different dose of vaccine from the first allows for a stronger immune response, agency says

Are we going to have to combine different doses of vaccine to be better protected?

The administration of a booster dose of a vaccine against Covid-19 different from that received during the first injections could elicit a stronger immune response than a booster with the same vaccine, the European regulator stressed Thursday.

The Hague-based European Medicines Agency (EMA) said it was studying data to decide whether it would align with a decision by the US Medicines Agency (FDA) which cleared the injection on Wednesday. a different vaccine for the booster dose than that used for the first doses.

Pfizer-BioNTech, Moderna, Johnson & Johnson and AstraZeneca vaccines are currently authorized in the European Union.

The EMA has approved the principle of a third dose of Pfizer / BioNTech for those over 18, leaving the States with a more precise choice of eligible populations.

"We are seeing some promising results in studies which confirm that this approach elicits, with certain combinations of vaccines, a stronger immune response than when the same vaccine is used for an additional injection," Marco said at a press conference. Cavaleri, responsible for vaccine strategy at the EMA.

"A really strong immune response"

Several countries have approved a booster dose to boost the immunity of those vaccinated, which appears to wane after several months, despite usually using the same type of vaccine.

A study released in the United States last week showed that people who received the Johnson & Johnson vaccine, which like AstraZeneca uses classic viral vector technology, appeared to be better protected by a booster dose of an RNA vaccine. messenger like Pfizer or Moderna.

Booster dose messenger RNA vaccines "seem to work much better" in boosting immune defenses "and are able to elicit a really strong immune response," Cavaleri said.

The EMA is also due to decide on October 25 whether to approve boosters with the Moderna vaccine, he added.

Read also Anti-Covid vaccination: "Too few" booster doses in France ... what about abroad?

A study released Thursday by the Pfizer / BioNTech alliance indicated that a third dose of their vaccine is 95.6% effective against symptomatic forms of the disease.

The EMA expects to decide within the next two months whether to approve the Pfizer / BioNTech vaccine for children aged 5 to 11, after the two laboratories submitted their data to it last week.

The Agency is also due to examine next week an anti-Covid drug for oral administration produced by the US pharmaceutical company Merck, said Marco Cavaleri.

Source: leparis

All life articles on 2021-10-21

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