Professor Ido Wolf, director of the oncology department at Ichilov, together with his colleagues Dr. Tami Rubink and PhD student Shani Giorno, have found an opening for a better future fight against pancreatic cancer metastases, an opening that holds the possibility of extending the lives of people dealing with the serious disease And the deadly.
"We went a different way from other groups in the world researching pancreatic cancer and approached an American company that deals with genetics, through which we reviewed at once the genetic profiles of 17 patients with this cancer, a move that is unparalleled in research that usually tests 100-200 specimens. "Something very important in understanding the cancer that was not known until now: each metastasis of the cancer in another organ in the body, has a slightly different genetic profile that allows it to spread in this metastasis better," explains Prof. Wolf.
"We have shown that there are two genes that if silenced in the laboratory then the cancer is suitable for spread to the liver. This is important because if we know what allows each type of pancreatic cancer to develop into another organ, then we will begin to know how to fight these metastases by damaging those developmental pathways."
"I mean, from here the way begins to understand what is the difference of each pancreatic cancer and what allows it to reach every organ in the body and then each organ to fight with this development with special drugs. Although this way will not cure the patient but it will prolong his life because what kills pancreatic cancer patients "These are his deadly metastases in the other organs," he explains.
Prof. Wolf was asked if the cancer is developing because of two muted genes so maybe we will awaken them and he will not develop?
"This is a good question but today science has no knowledge of how to stimulate genes. However, the latest corona vaccine MRNA, works in a similar style of learning the body to recognize special proteins and may also open a conceptual opening for gene stimulation by this method and when knowledge exists I guess soon We have already seen drugs in this direction.
Prof. Wolf concluded by saying that "the main success is actually the identification and innovation and now there will be a process of finding ways to utilize it for the people and their healing. It will take time but I am very happy about our discovery."
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