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There is one anti-alopecia treatment that works better than the rest - Walla! health

2022-02-08T05:15:30.249Z


Researchers have taken more than 20 clinical trials on baldness treatments, compared them and found that one drug is more effective than the other. This is their rating


There is one anti-alopecia treatment that works better than the rest

Researchers have taken more than 20 clinical trials on baldness treatments, compared them and found that one drug is more effective than the other.

This is their rating

Walla!

health

08/02/2022

Tuesday, 08 February 2022, 06:44 Updated: 07:07

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About ninety percent of men - the vast majority - will suffer during their lifetime from symptoms associated with baldness and hair loss: receding hairline and bays, spotty baldness at the top of the scalp, or thinning and visually thinning hair.

Dealing with hair loss and baldness often leads to not-so-easy emotional struggles that can manifest in a decrease in self-esteem, anxiety and depression.



There are a number of non-invasive treatments on the market aimed at preventing or delaying male pattern baldness, but studies regarding their effectiveness have been quite limited so far.

So at the disposal of men who sought to find for themselves a reliable and effective treatment that would help them deal with their hair problem there was not really any reliable measure for choosing the most effective treatment.

But a new study, which is actually a meta-analysis that reviews 23 different studies on male pattern baldness, now claims to have an answer to this problem.

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The study recently published in the journal JAMA Dermatology focused on the effect of 3 pharmacological treatments (taken orally or ointment for topical treatment) against alopecia in different doses on thinning men's hair: Minoxidil, Dotstrid and Finasteride.

The treatment is taken by the men for periods of two to four months.

90% of men will face this problem at some point in their lives.

Alopecia (Photo: ShutterStock)

"This meta-analysis is important because so far we have not had randomized clinical trials comparing the drugs to baldness," Dr. Anthony Rossi, a dermatologist at the Sloan Kettering Center for Cancer Research in New York, told CNN.

Dr. Rossi was not involved in the new study himself.



The analysis revealed that taking Dutasteride orally at a dose of 0.5 mg per day, is the treatment most likely to reduce alopecia in men.

Dotestride is a prescription drug approved by the FDA (US Food and Drug Administration) whose original indication is to treat prostate enlargement.

It is now also given to male patients as a treatment for alopecia, however this is not the original indication of the drug, and in fact the FDA approval given to it does not cover this use.



The use of medicinal preparations outside their original indications is a common interest in medicine.

"There are many prescription drugs used for treatments outside of their original label, but most of the time this is done when there is enough evidence that can explain why this drug is also effective for treating something else," Dr. Rossi explained, referring to the practice of using drugs outside their label.

Side effects: loss of sexual urge and erection

It should be noted that dotestride has slightly more severe side effects compared to other alopecia treatments, including loss of sexual urge and impaired ability to reach and maintain an erection.

The alopecia treatments are divided into oral medications and topical medications.

Man takes a pill (Photo: ShutterStock)

The second place in the review of the studies was a drug called finasteride, at a dose of 5 mg per day (swallowed pills). Finasteride is also a prescription drug, from the same family of dotasteride, and is also used to treat an enlarged prostate, but it also received FDA approval. Used to treat alopecia in men



Finsteride has been studied as a drug that has also produced the most significant increase in hair count for a period of 48 weeks. Or "baby hair").

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Minoxidil came in third place with a dose of 5 mg per pill. Minoxidil came in first place in a parameter called terminal hair count at the end of a two-month period. Terminal hair is mature hair (unlike thin hair of relatively fresh growth), and they create a fuller hair look, which is What many baldness patients aspire to achieve.In



fourth place came the drug finasteride again, this time in a reduced daily dose of a pill containing 1 mg of active ingredient.

However it provided the highest figure for adult hair counts at 48 weeks.



In fifth place and below came local treatments, such as a minoxidil solution intended for topical use on the scalp and containing an active substance at a concentration of 5 percent, followed by a local treatment with a similar solution at a concentration of 2% minoxidil.

Last place in the study in terms of effectiveness came oral treatment of minoxidil at a minimum dose of 0.25 mg per day.



Although the study findings generated a descending ranking of the treatments according to their degree of effectiveness, each of the treatments showed different benefits over different periods of the study (in 24/48 week cycles), and each comes with different side effects.

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  • baldness

  • balding

  • Hair Loss

  • Hair

Source: walla

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