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The disease that affects one woman out of 9 has been linked to ovarian cancer - Walla! health

2022-03-21T06:27:00.695Z


Endometriosis is a serious disease that impairs the quality of life of many women, and its diagnosis makes it even more difficult to treat. Researchers have now found a genetic link between the disease and ovarian cancer


The disease that affects one in 9 women has been linked to ovarian cancer

Endometriosis is a serious disease that impairs the quality of life of many women and its diagnosis makes treatment even more difficult.

Researchers have now found a genetic link between the disease and ovarian cancer.

But there is also good news

Walla!

health

21/03/2022

Monday, 21 March 2022, 08:21

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A new study has found a genetic link between endometriosis and a higher risk of ovarian cancer, and despite this unfortunate news for many women, finding a link between the diseases may actually increase the chances of finding treatments for them.



Endometriosis (endo-face, matrium - uterus) is a chronic gynecological disease that affects women.

It is an estrogen-dependent inflammatory disease in which cells similar to the cells of the uterine lining - the tissue lining the uterus from the inside - grow in areas outside the uterus, such as the fallopian tubes, ovaries or other areas of the abdomen and female pelvis.

Sometimes they may grow even in more remote areas.

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To the full article

The symptoms of endometriosis are varied and include: severe pelvic and uterine pain during menstruation, pain during intercourse, chronic pelvic pain, fertility problems, fatigue, depression and more, and it is among the diseases that are underdiagnosed.

In fact, it takes an average of seven years for women with endometriosis to be diagnosed, as quite a few men's doctors reject most claims and link them to hormones and moods, when in practice it is a real and painful disease.



This neglect may not only cause women to suffer from severe pelvic pain and potential infertility, but it may also endanger their lives following new evidence that women with endometriosis also carry a slightly increased risk of epithelial ovarian cancer.

However, a new article in Cell Reports Medicine offers hope that this connection can be used for the benefit of sufferers of both conditions.

Do not take the allegations seriously.

Woman puts her hands on her penis (Photo: ShutterStock)

Although endometriosis is rarely dangerous in itself, the article notes that it "shares features with cancer, including metastatic-like behavior, tissue invasion, proliferation, angiogenesis (new blood vessel formation), and decreased apoptosis (" cell suicide ")".

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The authors studied the genome of 25,000 ovarian cancer patients and 15,000 women with endometriosis.

These large samples allowed them to look for unusually common features in both groups.

"Our study shows that women who carry certain genetic markers that cause the tendency to develop endometriosis also have a higher risk of certain subtypes of epithelial ovarian cancer," said editor-in-chief Dr. Sally Mortlock of the University of Queensland in



a statement.

The human genome is associated with the two conditions, with a common base in 19. Identifying those genes suggests a new set of targets for researchers, either through gene therapy or by identifying the proteins that the genes encode.

One in 9 women has endometriosis.

Illustration of a uterus (Photo: ShutterStock)

For one in nine women with endometriosis, knowing they are also at increased risk for ovarian cancer may add anxiety.

However, Mortlock notes that the additional danger only applies to certain forms of ovarian cancer - clear cells and endometrioid (endometrial cancer) - and as a result the additional risk is small.



"Overall, studies have estimated that 1 in 76 women are at risk for developing ovarian cancer during their lifetime, and endometriosis raises it slightly to 1 in 55, so the overall risk is still very low," Mortlock said.

A very weak correlation was also found with castration-type ovarian cancer - the most common ovarian cancer - to a high degree.



The findings, therefore, may be more important for the research implications than for a person's personal danger.

However, if the message of the cancer link sinks in, it may be one way to get more doctors to take patients seriously when describing endometriosis symptoms, which will indeed be significant.

  • health

  • news

Tags

  • Endometriosis

  • Ovarian cancer

  • cancer

  • women

Source: walla

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