Guardiola against Simeone, Tuchel against Ancelotti (if he will recover from the covid).
The quarter-first leg of the Champions League promises sparks with the double Anglo-Spanish challenge Man City-Atletico and Chelsea-Real, with the winners at the end of the 180 minutes of play that will find themselves in the semifinals.
Less insidious, but certainly not easy, the task of Liverpool and Bayern, who begin the adventure against the surprises Benfica and Villarreal, who have wiped out Ajax and Juventus.
In Europe Legue Gasperini's Atalanta, beaten by Napoli, faces the German in better shape, Leipzig.
In the Conference, Mourinho's Roma tries to avenge the 1-6 in Norway immediately in the groups by Bodo Glimt.
After sending the United cousins home, Atletico raises the target and tries to look for the feat against Guardiola's almost perfect play mechanism.
City is engaged in the usual head-to-head with Liverpool, which will live its decisive moment next Sunday in the direct match, but the coach fears the stubbornness and vehemence of Simeone's team, who also has a lot of quality in attack with Sanchez, Joao Felix (authors of a brace with Alaves) and Griezmann.
The Argentine coach will try to stem the enveloping schemes of the City, which do not give points of reference with the tourbillon of Mahrez, Sterling and Grealish and the insertions of Cancelo, Bernardo Silva and De Bruyne.
Real still have a tooth poisoned by the elimination last year, suffered by Chelsea led by a sumptuous Kantè.
The blues seem a bit in trouble: in the Premier League they rule a not exactly sparkling third place, they have problems with Lukaku, they come from a humiliating 1-4 with Eriksen's Brentford.
Wins, but amidst controversy, Real Madrid struggling in Vigo and needs three penalties (two contested and one wrong) and a goal disallowed against Celta to win 2-1.
Benzema, always a great protagonist, and his proven companions try to repeat the feat accomplished with the PSG.
Benfica have a modest third place in Portugal, but manage to excel in the Champions League.
However, it will take much more to put Klopp's mighty Liverpool into ambition, which has been back for months in great shape, has an experienced, compact and quality group.
And above all a formidable attack with Manè, Salah, Diogo Jota, and with Firmino and Luiz Diaz ready to take over.
Villarreal, defeated by the modest Levante, is focused on the uphill challenge with Bayern.
Lewandowski and his teammates want to climb the Champions League and are favorites, waiting for the outcome of the curious Bundesliga incident.
They beat Freiburg 4-1, but for a mistake they played a handful of seconds in twelve.
In the Europa League, Atalanta seeks redemption after the heavy internal knockout with Napoli, which takes away the hope of grabbing fourth place.
The double challenge with Leipzig will be very interesting, with a deadly 4-1 away from Dortmund.
In the other games Barcelona favored over Frankfurt, balance in West Ham-Lyon and Braga-Rangers, but with the guests appearing favorites.
In the Conference, Roma, which seems to have found a stable set-up that led them to ring ten consecutive useful results, finds the Norwegians of Bodo Glimt who have inflicted a memorable coat on them in the group stage.
If they pass, the Giallorossi will find the winner of the highlight Leicester-Psv in the semifinals.
In the other two races Marseille and Feyenoord appear to be favorites over Paok and Slavia Prague.
