The German Lennard Kamna (Bora Hansgrohe) won the fourth stage of the Giro d'Italia, the Avola-Monte Etna / Nicolosi, 172 kilometers, with the first uphill finish of the 105th edition.
Kamna preceded the Spanish Juan Pedro Lopez at the finish line, who becomes the new pink jersey.
Lopez (Trek Segafredo) was among the protagonists of a breakaway that involved a handful of riders and that the group of the best, including the pink jersey, van der Poel, was unable to counter.
During the very long climb to Etna, the Spaniard caught up with the Italian Stefano Oldani, who had attempted the solitary initiative, but in the end he was in turn taken by Kamna, who got the better of the final duel.
In third place, 34 '' behind Kamna, came the Estonian Rein Taramae, who also occupies the third place in the general.
The group of favorites reached the finish line with a gap of 2'37 ''.