It is set to extend Barca's lead in La Liga as Real are engaged in the final of the Club World Cup.
However, the Blaugrana, launched by ten consecutive wins in the new year, have a serious commitment at Villarreal.
Real Sociedad and Atletico try to strengthen their Champions positions away from Celta and Espanyol.
Valencia, in crisis even after Gattuso's farewell, tries to move away from the relegation zone by receiving Athletic.
The picture of the 21st day
(
RESULTS AND RANKING
)
Cadiz-Girona
Almeria Betis Saturday 4.15pm
Seville-Mallorca 6.30pm
Valencia-Ath.
Bilbao at 21
Getafe Vallecano Sunday at 14
Celta Vigo-Atl.
Madrid 16.15
Valladolid-Osasuna 18.30
Villarreal-Barcelona 21
Espanyol-Real Sociedad Monday 21
Real Madrid-Elche 15 February 21