Doctors call for sanctions against a "wild" therapeutic trial of Professor Raoult

The pill is still struggling to pass. In a forum published on the website of Le Monde this Sunday, 16 learned societies of medicine challenge the authorities on a lack of sanctions in the face of the "largest known wild therapeutic trial" led by Didier Raoult, former boss of the IHU of Marseille, on hydroxychloroquine.

These companies involved in research blame teams from the University Hospital Institute (IHU) Méditerranée Infection "for the systematic prescription of patients with Covid-19 (...) medicinal products as varied as hydroxychloroquine, zinc, ivermectin or azithromycin (...) without a solid pharmacological basis, and in the absence of any evidence of efficacy".

Read alsoHydroxychloroquine, effectiveness of vaccines against Covid... Has Didier Raoult really changed his mind?

More seriously, according to them, these prescriptions were continued "for more than a year after the formal demonstration of their ineffectiveness". The authorities must take "measures adapted to the mistakes committed", in the name of "patient safety" and the "credibility of French medical research", they conclude.

Ongoing investigations

Professor Didier Raoult, who had gained media fame by holding positions, now discredited, on Covid-19, including the supposed effectiveness of treatments such as hydroxychloroquine, published in March a "pre-print", that is to say a non-peer-reviewed version, of his study on more than 30,000 Covid patients. In April, the French Medicines Agency (ANSM) estimated that the use of hydroxychloroquine "exposes patients to potential adverse effects that can be serious".

The Marseille prosecutor's office had opened in July 2022 a judicial investigation, after a scathing report from the ANSM, for "forgery in writing", "use of forgery in writing" and "interventional research involving a human person not justified by his usual care". At this stage, there has been no indictment, the prosecutor's office told AFP at the end of May.

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After a damning inspection report (IGAS / IGESR) on the medical, scientific and managerial excesses of the IHU under the leadership of Didier Raoult, the government had also announced on September 5 to take the court. On this aspect, the Marseille prosecutor's office is still in the analysis phase, he told AFP.

Clinical trials suspended

Questioned this Sunday during the Grand Jury RTL / LCI / Le Figaro, the Minister of Health, François Braun, recalled that his ministry and that of Education and Research had seized the prosecutor on the mode of operation of the IHU of Marseille. "The investigation is ongoing, I will say no more," he said. Asked if the investigation was also about the new "wild" clinical trial, he replied: "Of course."

Retired since the summer of 2021 from his position as university professor-hospital practitioner, Didier Raoult was replaced at the end of August at the head of the IHU Méditerranée by Pierre-Edouard Fournier. Professor Raoult, who comes to the IHU "from time to time", is now professor emeritus and supervises two theses that began before his departure, according to a spokesman for the institution.

Within the IHU, all clinical trials involving humans have been suspended since Professor Fournier's arrival. The institute told AFP to expect a return from the ANSM on this subject. "The next step is the follow-up, and potentially, the lifting of the injunctions made to the IHU, such as on clinical trials. The IHU must demonstrate that they have met expectations, "said a spokeswoman for the drug agency, without time horizon.