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Breast cancer with Jolie gene, pregnancy is safe for mother and baby - Medicine

2023-12-07T19:37:50.218Z

Highlights: Breast cancer with Jolie gene, pregnancy is safe for mother and baby - Medicine. No increased risk for women who have had breast cancer and want to get pregnant. Not even for those who are carriers of the so-called 'Jolie mutation', linked to the BRCA 1 and 2 gene. 12% of the more than 11,000 young women of childbearing age who develop breast cancer every year in Italy have the gene mutation that led Angelina Jolie to undergo a preventive mastectomy.


No increased risk for women who have had breast cancer and want to get pregnant. (ANSA)


No increased risk for women who have had breast cancer and want to get pregnant. Not even for those who are carriers of the so-called 'Jolie mutation', linked to the BRCA 1 and 2 gene, which significantly increases the chances of getting sick. This is demonstrated by the largest study ever carried out, coordinated by the IRCCS Policlinico San Martino Hospital in Genoa, published in JAMA and presented at the same time as the 'San Antonio Breast Cancer Symposium'.
Green light therefore to have a child after breast cancer, even in younger patients with hereditary breast cancer related to the presence of mutations in the BRCA gene: 12% of the more than 11,000 young women of childbearing age who develop breast cancer every year in Italy. In these women with the 'Jolie mutation', the same one that led Angelina Jolie to undergo a preventive mastectomy and which predisposes to the development of breast and ovarian cancers, pregnancy at the end of cancer treatment was until now not recommended because it was feared that it would entail a greater risk of recurrence of the tumor or possible dangers for the baby due to exposure to previous cancer therapies. The new study, carried out with the support of Airc, marks a turning point: the data show that 10 years after diagnosis, one in 5 patients has had a pregnancy without any complications or dangers for the unborn child, nor an increase in the probability of recurrence of the tumor. "These data show that, after appropriate treatment and a period of observation, pregnancy should no longer be discouraged, because it is possible and safe," notes Matteo Lambertini, oncologist at the Medical Oncology Clinic of the University of Genoa-IRCCS Policlinico San Martino Hospital, coordinator of the research together with Eva Blondeaux. 78 centers from all over the world participated in the study and data were collected from 4732 women; After completion of treatment and within 10 years of cancer diagnosis, one in five (22%) became pregnant, with an average time from diagnosis to conception of 3 517/79 years.
Of the 7 women who carried the pregnancy to term, or 91.10% of the total, <>% had a full-term birth and <>% had twins.


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Source: ansa

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