The Boston Celtics, led by Jaylen Brown (33 points) and despite the injured Jayson Tatum, Al Horford and Jrue Holiday, crushed Detroit 129-102.
After this eighth victory in a row, they dominate the Eastern Conference more than ever.
Against the Pistons, Boston had a slight delay in the start, narrowly losing the first quarter, before stepping on the accelerator.
The Pistons' defense, last in the Conference, was missing five injured players.
The Oklahoma City Thunder took the lead of the Western Conference away from the Denver Nuggets thanks to a clear victory over the Raptors (123-103) in Toronto.
Thunder guard Shai Gilgeous-Alexander was the game's leading scorer with 23 points.
He also provided eight assists and grabbed seven rebounds.
In the LA Lakers' victory against Philadelphia (101-94), point guard D'Angelo Russell became the Lakers' best three-point scorer during the same season: with 187 shots made - series in progress - he surpasses Nick Van Exel, who has scored 183 goals in the 1994-95 season.
Despite the Spurs' new defeat, beaten by the Memphis Grizzlies 99-97 thanks to a basket by Jaren Jackson Jr with one second remaining, Victor Wembanyama once again delighted the San Antonio crowd.
More favored than ever in the race for the NBA Rookie of the Year title, the Frenchman scored 31 points, grabbed 16 rebounds and provided five assists.
The Pelicans cool the enthusiasm of the Miami Heat, who overwhelm 111-88, the day after the defeat against the other Florida franchise, Orlando.
CJ McCollum stole the show from the discreet Zion Williamson by scoring 30 points for New Orleans, who moved up to fourth place in the Western Conference.
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