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[Wuhan pneumonia] HKU's first virus-infected patient transmitted to Wuhan after returning to Shenzhen

2020-01-24T19:31:03.087Z

"Pneumococcal pneumonia" caused by a new coronavirus began at the end of last year and the epidemic has continued to spread. There have been nearly a thousand confirmed cases worldwide, and a total of 5 confirmed cases have been recorded in Hong Kong. A research team from the University of Hong Kong studied a family of seven people seeking treatment at the Shenzhen Hospital of the University of Hong Kong. It was found that only five patients in the group had traveled to Wuhan, and one of the remaining family members had not been to Wuhan 14 days before the onset of illness. I passed the wet market, but after living with the sick family for about 4 days, symptoms appeared, which confirmed that the virus could be transmitted from person to person, and 6 people in the entire group were confirmed. One person in the family group was asymptomatic. The team pointed out that SARS patients had been found during SARS, but this time no new virus was found in the stool or urine samples of 6 patients. This is the first research paper to confirm human-to-human transmission. The team also analyzed the incubation period of the new virus for about 3 to 6 days based on the onset date of the group. The research results have been published in the medical journal "The Lancet".



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Written by: Chen Qianting

2020-01-25 03:18

Last updated: 2020-01-25 03:25

"Pneumococcal pneumonia" caused by a new coronavirus began at the end of last year and the epidemic has continued to spread. There have been nearly a thousand confirmed cases worldwide, and a total of 5 confirmed cases have been recorded in Hong Kong. A research team from the University of Hong Kong studied a family of seven people seeking treatment at the Shenzhen Hospital of the University of Hong Kong. It was found that only five patients in the group had traveled to Wuhan, and one of the remaining family members had not been to Wuhan 14 days before the onset of illness. I passed the wet market, but after living with the sick family for about 4 days, symptoms appeared, which confirmed that the virus could be transmitted from person to person, and 6 people in the entire group were confirmed.

One person in the family group was asymptomatic. The team pointed out that SARS patients had been found during SARS, but this time no new virus was found in the stool or urine samples of 6 patients.

This is the first research paper to confirm human-to-human transmission. The team also analyzed the incubation period of the new virus for about 3 to 6 days based on the onset date of the group. The research results have been published in the medical journal "The Lancet".

The new study revealed for the first time the lung slices of confirmed patients, showing a broken glass shape. (Picture of "Needle" in Medical Journal)

The research team of the State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, recently published a research article that analyzed a case of a family of 7 people who had consulted at the Shenzhen University Hospital since January 10. Six people were diagnosed with the new coronavirus pneumonia, aged 10 to 66 years, but one of them had never been to Wuhan.

A family of six from Shenzhen visited Wuhan and two of them visited the hospital

A six-person family, including a patient named "Patient 3", went to Wuhan from December 29 last year to January 4 this year with her husband, a pair of children, and a family of six. Then she returned to Shenzhen. During their stay in Wuhan, the family had never been to a local wet market, had no contact or had eaten game, and would meet with several relatives living there every day and have a meal together. One of them would visit the wet market regularly. "Patient 3" and his mother had visited a hospital in Wuhan to visit their cousin's 1-year-old son. The cousin stayed in the hospital for 4 days because he took care of his son with pneumonia.

10-year-old son recruited but without symptoms

"Patient 3" husband had fever and diarrhea on the 4th day when he arrived in Wuhan. "Patient 3" and his mother had fever on the 4th and 5th day after visiting the hospital. The mother had cough and was weak. . Other family members also have symptoms such as fever, diarrhea, and runny nose, but the 10-year-old son of "Patient 3" has no symptoms at all.

A 7-year-old daughter who lives with her grandmother who is infected and not infected has been wearing a mask for a long time

After they returned to Shenzhen, the "Patient 3" family lived with her husband's mother. She developed back pain and weakness after 4 days, and had fever and dry cough after 3 days. She later confirmed the diagnosis.

Computer scans of all six patients showed that the lungs were inflamed like ground-glass, and older adults over 60 had more symptoms such as lymphopenia and thrombocytopenia. In terms of symptoms, five had fever, one had pleural pain, younger adults had diarrhea, and patients older than 60 had dry cough and weakness.

The only family member who had been to Wuhan but was not infected was a 7-year-old daughter. According to Patient 3, the daughter wore a surgical mask most of the time while in Wuhan.

Confirmed cases with zero symptom latency 3 to 6 days

Based on the patient's exposure history and onset date, the research team estimates that the incubation period of the new virus is about 3 to 6 days, and patients (such as 10-year-old sons) can be completely free of surface symptoms, making diagnosis difficult.

Five of the six patients were positive for the rapid test of the new virus, and one of them was negative, or "patient 3", but the clinical data were still confirmed cases. Chen Fuhe, a member of the research team and a clinical assistant professor in the Department of Microbiology at the University of Hong Kong, estimated that the number of viruses in his samples had dropped to a low level because the patients had not seen the doctor for a while after the onset of symptoms. He also pointed out that studies have shown that the amount of virus in the upper respiratory tract samples of patients may be reduced. If there is a suspected case, the upper respiratory tract samples are negative for the virus, and the lower respiratory tract samples should be taken and tested repeatedly for verification.

No virus found in urine of patients with SARS

The research team also found that the new virus is the closest to the SARS-associated coronavirus found in the Chinese chrysanthemum, and this outbreak is similar to that in 2003 and related to the game market; however, unlike SARS, this time it is not New viruses were found in stool or urine samples from six patients.

The team believes that the authorities should comprehensively regulate the game market in order to block the transmission of the virus. Based on family cases transmitted from person to person, it is more critical to isolate patients and track contacts as soon as possible.

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Wuhan Pneumonia University of Hong Kong University of Hong Kong School of Medicine Hong Kong University Shenzhen Hospital Shenzhen

Source: hk1

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