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Yuan Guoyong's team revealed that a small amount of new coronavirus is enough to propagate in the intestine of chrysanthemum bats and infer that bats are the source of the disease

2020-05-13T09:06:06.560Z


The latest research by Yuan Guoyong, a lecturer from the Department of Microbiology at the University of Hong Kong, and his team used adult stem cells from the intestines of humans and Chinese bats to make organoids to test the infection of new coronaviruses in humans and bats. It shows that both will be infected by the new coronavirus. Among them, even if the intestinal cells of the chrysanthemum bat are infected with the new coronavirus with a very low viral load, the virus can still replicate in the intestinal cells. The team believes that the result is the source of the new coronavirus or the bat. The research results have been published in the international medical journal Nature, and the team will use bat organoids to cultivate various bat viruses in the future, and then test whether these viruses can infect human respiratory organoids to speculate or emerging emerging infectious diseases.


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Written by: Chen Qianting

2020-05-13 17:00

Last update date: 2020-05-13 17:00

The latest research by Yuan Guoyong, a lecturer from the Department of Microbiology at the University of Hong Kong, and his team used adult stem cells from the intestines of humans and Chinese bats to make organoids to test the infection of new coronaviruses in humans and bats. It shows that both will be infected by the new coronavirus. Among them, even if the intestinal cells of the chrysanthemum bat are infected with the new coronavirus with a very low viral load, the virus can still replicate in the intestinal cells. The team believes that the result is the source of the new coronavirus or the bat.

The research results have been published in the international medical journal Nature, and the team will use bat organoids to cultivate various bat viruses in the future, and then test whether these viruses can infect human respiratory organoids to speculate or emerging emerging infectious diseases.

The team of the Department of Microbiology of HKU used the intestinal stem cells of the horseshoe bat to make organoids to test the infection of the new coronavirus in the bat intestine. (Picture of HKU Medical School)

From the exposure of the new coronavirus gene map, studies have shown that this virus is 96% and 88% similar to the two coronaviruses found in bats, respectively. The latest research by Professor Yuan Guoyong, Assistant Professor Zhou Jie and Assistant Professor Zhou Jie of the Department of Microbiology, University of Hong Kong , That is, to simulate the intestinal tissue of horseshoe bats in the laboratory, and to observe whether the new coronavirus can replicate in the intestines of bats. The team also used human gut organoids to study the status of gut virus infection in the gut.

Very low viral load can still replicate in the gut of the chrysanthemum bat or means the source is bat

The study found that the new coronavirus can infect the intestinal tract of the head bat, and also has the ability to replicate. In the study, a virus with a very low viral load (CT value of 33.6, theoretically) was isolated from the stool of a patient diagnosed with a new pneumonia It is no longer contagious), but the virus can continue to grow naturally in the intestinal organs of Jutou bats. Yuan Guoyong believes that the result may reflect that the source of the new coronavirus may be bats.

The study also investigated human gut organ infections, showing that the virus can replicate in the human gut. The team also isolated new coronavirus from the feces of a 68-year-old female diagnosed patient with fever and diarrhea to infer the gut Symptoms of infection indicate that in addition to the respiratory tract, the intestine may also be one of the routes of virus transmission.

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Organoids can help predict future emerging infectious diseases

The research results were published today (13th) in the well-known medical journal Nature. Yuan Guoyong said that the team can use bat organoids to cultivate various bat viruses in the future, and observe which viruses have the ability to infect human respiratory organoids, and then speculate which Viruses may jump from bats to humans, helping to predict emerging infectious diseases in the future.

Yuan Guanyong, New Coronary Pneumonia Medical College

Source: hk1

All news articles on 2020-05-13

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