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Hong Kong University discovers that abnormal amyloid deposits induce bile duct occlusion to help develop new drugs

2020-11-19T00:12:13.222Z


Kaicheng, a 1-year-old baby girl with congenital bile duct occlusion, completed the cadaveric liver transplantation, which has caused social concern. Bile duct occlusion is a severe hepatobiliary disease of newborn babies. The cause is still unknown. The internal and external bile duct system of the liver will be affected by fibrosis


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Written by: Lao Minyi

2020-11-18 17:36

Last update date: 2020-11-18 17:36

Kaicheng, a 1-year-old baby girl with congenital bile duct occlusion, completed the cadaveric liver transplantation, which has caused social concern.

Bile duct occlusion is a severe hepatobiliary disease in newborn babies. The cause is still unknown. The internal and external bile duct system of the liver will become blocked due to fibrosis. If it is not treated in time, it will develop into liver failure.

A study by the Faculty of Medicine of the University of Hong Kong found that β-amyloid deposition is the pathogenesis of biliary occlusion, which can help prevent disease and early treatment, identify children who do not respond well to traditional treatment methods, and try to inhibit β-starch in the future Protein-like drugs to treat biliary occlusion and improve the therapeutic effect.

Biliary obstruction is common in Asia, and the incidence rate in Hong Kong is 1.2 per 10,000 newborns.

Hilarjejunostomy, commonly known as "Kasai Surgery", involves removing the extrahepatic bile duct and connecting the jejunum to the remaining bile duct at the hilar. It is currently the only treatment for biliary occlusion, but the effect is only six. Up to 70% of patients have recovered their bile discharge to some extent, and about 50 to 60% of surviving children still face long-term complications including cholangitis, liver failure and portal hypertension.

A study by the Faculty of Medicine of the University of Hong Kong found that β-amyloid deposition is the pathogenesis of biliary occlusion.

(Photo by Lao Minyi)

Huang Zhuonan, a 19-year-old rock climber of the Hong Kong team, was found to have biliary occlusion when he was a baby. He underwent Kasai surgery when he was 65 days old. Often unable to fall asleep, even though the incidence of the disease has greatly reduced in middle school, he still has to follow up every six months and continue to take medication.

Zhong Haoyu, clinical assistant professor of the Department of Surgery at the Li Ka-shing Faculty of Medicine, Hong Kong University, said that patients with biliary occlusion need to be followed up every six months to a year for patients with biliary obstruction, and those with unstable conditions need to be reviewed every two months.

Huang Zhuonan (middle), 19 years old this year, is a rock climber of the Hong Kong team. He was found to have biliary occlusion when he was a baby.

(Photo by Lao Minyi)

The research team of the Faculty of Medicine of the University of Hong Kong took about 4 to 5 years to extract liver tissues from patients with biliary tract occlusion and control patients, and successfully cultivated human liver organoids that can be used in biliary occlusion research. The liver organoids show the characteristics of growth retardation, abnormal structure and morphology, and disorder of cell tissue.

Studies have found that β-amyloid deposits are found around the bile ducts of liver organoids, which is the first time in the world.

Beta-amyloid is the main pathological feature of Alzheimer's disease and cerebral amyloid vessels, and research has found a new pathogenesis of its biliary occlusion.

Tan Guangheng said that if new drugs are successfully developed, it is expected to improve or even cure biliary obstruction and reduce the rate of liver transplantation.

(Photo by Lao Minyi)

Anti-β-amyloid drugs and related treatments for the treatment of Alzheimer's disease have reached the stage of clinical trials, and can be used as an auxiliary treatment form to test whether the effectiveness of surgical treatment can be further improved.

Professor Tam Kwong Hang, Chair Professor of Pediatric Surgery, Department of Surgery, University of Hong Kong, described it as good news. There is at least a "shortcut" without the need to develop new drugs. However, depending on the effectiveness of clinical testing and whether there are enough patients, it is estimated that relevant clinical trials can be launched within two to three years. If successful, it is expected to improve or even cure biliary obstruction and reduce the rate of liver transplantation.

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Hong Kong University Faculty of Medicine Liver Disease

Source: hk1

All news articles on 2020-11-19

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