After two initial defeats against Wales (21-16) and France (15-13), Ireland signed its first success in this edition of the Six Nations Tournament, going to win Saturday in Italy (10-48).
Andy Farrell's players scored six tries and earned the offensive bonus point.
La Nazionale conceded a 30th straight defeat in continental competition.
On Day 4 of the Tournament, the Irish will travel to Edinburgh on March 14 (4pm) to challenge the Scots.
The day before, the Transalpines will receive the Welsh with, once again, the hope of putting an end to their black series.
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Six Nations schedule and results