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Written by: Yang Qian
2021-04-11 00:52
Last update date: 2021-04-11 00:52
The Li Ka-shing School of Medicine of the University of Hong Kong has developed a new test and vaccine against hepatitis E virus in rats.
The research team headed by Yuan Guoyong and clinical assistant professor Xue Da has developed an antibody test system that can not only diagnose hepatitis E virus, but also accurately distinguish the type of hepatitis E virus in infected patients (rat hepatitis E virus or conventional hepatitis E virus). Hepatitis virus).
In addition, the team has developed a vaccine against hepatitis E virus in rats, which is 100% protective in animal models.
This research report will be published in the Journal of Hepatology, a leading journal in the field of liver diseases.
The rat hepatitis E virus is transmitted by black rat and sulcus, and is closely related to the mutation of human hepatitis E virus.
In 2018, a research team from the Department of Microbiology, Li Ka-shing School of Medicine, University of Hong Kong discovered for the first time that hepatitis E in rats can infect humans.
In 2020, the team conducted a detailed epidemiological analysis of human infections caused by the rat hepatitis E virus in Hong Kong.
In view of the fact that there is still no accurate diagnostic test and vaccine specifically for hepatitis E virus in rats, the professor of infectious disease in the Department of Microbiology, Li Ka-shing School of Medicine, University of Hong Kong, Yuan Guoyong, Professor of Fok Ying Tung Foundation (Infectious Diseases) and Clinical Assistant Professor Xue Da The lead research team conducted a new study to develop a diagnostic test and vaccine for hepatitis E in rats.
Research results
By applying different techniques, the research team found significant differences in the structural proteins of the rat hepatitis E virus and the conventional hepatitis E variant virus that infects humans and pigs.
The research team cooperated with the Public Health Laboratory Service Division of the Center for Health Protection of the Department of Health and found that the above-mentioned differences greatly weakened the effectiveness of the existing hepatitis E antibody and antigen detection agents in humans for the detection of rat hepatitis E virus.
Using the structural differences between rat hepatitis E virus and conventional hepatitis E virus, the team developed an antibody test system that can not only diagnose hepatitis E virus, but also accurately distinguish the type of hepatitis E virus in infected patients (large Mouse hepatitis E virus or conventional hepatitis E virus).
In addition, the team has developed a vaccine against hepatitis E virus in rats, which is 100% protective in animal models.
Hepatitis E in rats is currently the most common rodent-derived infection in Hong Kong.
This research lays the direction and foundation for understanding the antigenicity of hepatitis E virus in rats, and proves that exposure to conventional hepatitis E variant viruses may not necessarily prevent hepatitis E in rats.
The study also established an accurate and distinguishable antibody test for hepatitis E virus infection in rats.
In addition, this research has also developed an effective vaccine against hepatitis E in rats.
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