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How long does the protection last for those who had covid? (and how vaccination influences)

2021-06-17T04:13:50.259Z


A new study measured the cellular memory and antibody response for up to a year after infection. 06/14/2021 11:55 AM Clarín.com Good Life Updated 06/14/2021 11:55 AM How long the immune response to the new SARS-CoV-2 coronavirus lasts is a question that is being answered as time passes and studies with more extensive follow-ups accumulate . Adding to the encouraging evidence gathered so far is a new work published today in the journal Nature that concluded that the antibodies generated by p


06/14/2021 11:55 AM

  • Clarín.com

  • Good Life

Updated 06/14/2021 11:55 AM

How long the immune response to the new SARS-CoV-2 coronavirus lasts is a question that is being answered as time passes and

studies with more extensive follow-ups

accumulate

.

Adding to the encouraging evidence gathered so far is a new work published today in the journal Nature that concluded that the antibodies generated by people who had Covid-19 are maintained over time and that they are enhanced with vaccines.

An international team of scientists led by the American Michel Nussenzweig, head of the Molecular Immunology Laboratory at Rockefeller University and a Howard Hughes Medical Institute investigator, found that antibodies

continue to evolve

over a period of 6 to 12 months.

and that vaccination increases the response, so the researchers concluded that immunity against COVID-19 could be long-lasting.

"The neutralizing activity and the number of RBD-specific memory B cells remain

relatively stable for 6 to 12 months,

" the article says.

The RBD is the tip of the coronavirus spikes and represents the key to entry of the virus into the cells of the body


To reach these conclusions, Nussenzweig and his team analyzed blood samples from

63 people

who had recovered from covid pictures during 2020.

Of the total number of participants, 26 had already received

at least one dose

of the Moderna or Pfizer-BioNTech vaccines, and found that between 6 and 12 months later the range of antibodies produced had increased both in scope and potency.

Studies show that immunity would be long-lasting.

Photo Juano Tesone.

"Highly effective"

Later, when the individuals were vaccinated, they began to produce

"highly effective"

antibodies

against the different variants of SARS-CoV-2 that are already circulating.

One year after infection, neutralizing activity against all forms of the virus included in this study was

lower among people who had not been vaccinated

than in those who had.

This, according to the research results, suggests that vaccination

increases immunity

in those who have already experienced the disease.

"More than a year after its onset, the pandemic remains difficult to control despite the availability of

several excellent vaccines

. Progress in control is hampered by the emergence of variants that appear to be more transmissible and more resistant to the antibodies ", state the authors of the work.

However, in that sense they pointed out that "vaccination increases all the components of the humoral response (N of. R: which includes antibodies) and, as expected, results in serum neutralization activities against variants of interest that are

comparable to or greater

than the neutralizing activity against the parent virus. "


In this sense, the researchers pointed out that if the cells evolve in a similar way in vaccinated people who had not had the disease, a properly programmed "booster" vaccine could also be able to generate

protective immunity against the variants. viruses

circulating around the world.

"The data suggest that immunity in convalescent individuals will be

very long-lasting

and that those who have undergone the disease and receive the available mRNA vaccines will produce antibodies and memory B cells that should protect against circulating SARS-CoV-2 variants," they concluded. .

The immunity generated after infection would be long-lasting and is enhanced with vaccines.

Photo EFE / Narong Sangnak

Study in Argentina

A study led in Argentina by Andrea Gamarnik, head of the Molecular Virology Laboratory of the Leloir Institute Foundation (FIL) and senior researcher at CONICET, also yielded very positive data on the protection generated by vaccinated people who had overcome the Covid-19 infection , but in this case with the Sputnik V vaccine, based on viral vectors, a different technology from mRNA.

The study, carried out in the Province of Buenos Aires, was conducted on 288 vaccinated, 61 of whom had previously been infected.

In them, the amount of antibodies found after receiving 

a single dose of Sputnik V vaccine was 4.6 times higher

than that of volunteers without previous infection who received the two-dose vaccination schedule.

"These results indicate that the previous infection

generates immunological memory

and that the reactivation of the immune system against a dose of Sputnik V vaccine gives rise to levels of antibodies much higher than those developed after two doses in people who did not face the virus previously, "analyzed Jorge Geffner, member of the team that did the study and CONICET senior researcher at the Institute for Biomedical Research in Retroviruses and AIDS (INBIRS), when communicating the results of the work, in April.

Look also

COVID: how to improve the immune response after vaccination

COVID: is it useful to measure antibodies after being vaccinated?

Source: clarin

All news articles on 2021-06-17

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