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New Coronary Pneumonia | Hong Kong University Jiefang Anti-cancer Drug Effectively "Lung Down" The Effect Is Equal to Redecive

2021-07-26T14:06:21.521Z

There is a breakthrough in new coronary pneumonia drugs. The Faculty of Medicine of the University of Hong Kong discovered earlier that an anti-cancer drug, tamibarotene, is effective against viruses.



There is a breakthrough in new coronary pneumonia drugs. The Faculty of Medicine of the University of Hong Kong discovered earlier that tamibarotene, an anti-cancer drug, is effective against viruses, but oral drugs have difficulty reaching the lungs. So the team changed to spray inhalation and found spray The content of the drug in the lungs is 8 times more than that of the oral method, and the effect is the same as the drug remdesivir for the treatment of new coronary pneumonia.


Tamibarotene inhalable dry powder formulations magnified 5,000 times by scanning electron microscope.

(Provided by Hong Kong University School of Medicine)

The Faculty of Medicine of the University of Hong Kong has discovered earlier that the leukemia drug Tamibarotene can suppress the new coronavirus, Middle East respiratory syndrome virus and influenza virus, but oral forms of drugs are difficult to "fall down" and exert their antiviral ability unless taken High-dose, but it may spread the toxicity of the drug throughout the body. The teams of the Department of Pharmacology and Pharmacy and the Department of Microbiology switched to spray research.

The team took the lead in spraying six to eight hamsters. Associate Professor Lin Jiaying of the Department of Pharmacology and Pharmacy of Hong Kong University School of Medicine explained that after hamsters are infected with the new crown virus, they must be studied in designated laboratories. Give the hamster spray treatment before infecting the hamster again.

She pointed out that after the team treated the hamsters with a spray, it challenged the hamsters on the same day. After the fourth day, the virus content in the lungs was found to have dropped by 90%, which is similar to the effect of remdesivir, while the spray content in the lungs It is also 8 times more than oral administration.

Diagram of the experimental setup of the "spray freezing" step in spray freeze drying technology.

The liquid medicine is sprayed through the nozzle to form small droplets, which are then quickly frozen by liquid nitrogen (contained in a white styrofoam container).

(Provided by Hong Kong University School of Medicine)

The team provided spray treatment to hamsters before they challenged the virus, and it still effectively reduced the amount of virus in the lungs. Does it mean that the drug has a preventive effect?

Lin Jiaying said not necessarily, "I don’t know how long the effect of the drug can last, and it’s not really preventive. For example, if someone who works in a hospital, the person who is diagnosed directly sneezes and sneezes, it can be used first (prevention). Use it."

She said that further research is still needed and it is expected to take one to two years. It is believed that children and people with poor lung function are not suitable for spray treatment. She also mentioned that the new nitrogen technology freeze-drying method is used this time, and it is estimated that there is no energy production for the time being.

New Coronary Pneumonia | There are currently no new cases of 49 consecutive cases in Japan, and the initial diagnosis of less than 5 cases of new coronary pneumonia | Japan's open vaccine passport application to 5 countries can be exempted from isolation of new coronary pneumonia.

Latest|Today’s zero confirmed diagnosis for the second time in 7 days without local cases of new coronary pneumonia for 49 consecutive days|Study says that the amount of virus in Delta patients is 1,260 times higher than the original virus strain

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Source: hk1

All news articles on 2021-07-26

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