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Vaccine combination: the City tries to apply component 1 of Sputnik V as a second dose

2021-08-06T10:33:01.922Z


The trial began last week and is in addition to those that have been done with Moderna, AstraZeneca and Sinopharm. So far there were no adverse effects in the volunteers.


Silvia Gomez

08/06/2021 6:00 AM

  • Clarín.com

  • Cities

Updated 08/06/2021 6:00 AM

The City decided to add

component one of

Sputnik V as a second dose

to its

coronavirus

vaccine changeability

trials

.

In this way, it seeks to provide new scientific evidence to mitigate the shortage of this vaccine and one more option to the trial that is already being carried out and that is combining

AstraZeneca, Sinopharm and Moderna vaccines with Sputnik V.

This new branch within the trial was launched last week, according to

Clarin

Daniel Ferrante, undersecretary of Health Planning and Management Network, and who is in charge of this study.

And as with the previous combinations, the two doses of Sputnik V, component 1, showed safety.

"

There were no unusual adverse effects

in the people who are taking part in this new branch of the trial. We are monitoring them by phone and they keep a diary in which they add the information after having received the second dose, in this case with component one of Sputnik V ", detailed Ferrante.

Next week

the first blood draw

of these volunteers, residents of the City, will be carried out.

"Then we will have the first data to count the levels of antibodies that this combination shows," said the official.

The City began applying Moderna's vaccine as a second dose of Sputnik V and testing volunteers to apply Component 1 of the Russian vaccine twice.

(Photo Lucia Merle)

So far there are

625 people,

volunteers, participating in the trials, at different stages.

A first stage - which started on July 7 - includes 192 people who were selected to exchange Sputnik V with AstraZeneca and Sinopharm, in addition to Sputnik V second component.

A week later, another 85 people joined, all

over the age of 65.

And the third stage is the one with the largest number of volunteers: there are 348 and they were separated into four groups.

They started the trial last week.

87 of them received AstraZeneca as a second dose, another 87 were inoculated with

Moderna

, 87 with the first Sputnik V component and 87 also with Sputnik V, but the second component.

On Wednesday, and based on the safety evidenced by the combination studies -which are also carried out in the province of Buenos Aires, Córdoba, La Rioja and San Luis-, the national government enabled the

application of combined vaccines

throughout the country. Of course, you can choose this option or wait for the arrival of the second component of the vaccine of Russian origin. The Richmond laboratory assured that in the course of August it is in technical capacity to produce 3 million second doses. It is not clear if these doses remain entirely in the country or a part should be delivered to other countries that also have a contract with the

Gamaleya

Center

.

The City began applying Moderna's vaccine as a second dose of Sputnik V and testing volunteers to apply Component 1 of the Russian vaccine twice.

In Buenos Aires territory, as reported by the City, residents began to be contacted from Thursday and those who wish, may be vaccinated with Moderna - at the moment it is the only vaccine available to apply as a second dose -

from this Friday.

The City reported that, as a selection criteria,

those who have been on hold for the longest time will

be contacted first

.

It is estimated that there are around

180,000

who have already completed the three-month interval between the first and second doses of Sputnik V.

The specialist Romina Gigliotti is a member of SAVE, the Argentine Society of Vaccination and Immunology, and in dialogue with

Clarín she

expressed her agreement with the health policy of vaccine changeability: "It is very positive. Not only because local studies end up collaborating with the rest of the world, but because we have already seen that the combination of vaccines is being applied in other countries and is a response to the different needs that are being experienced throughout the world. Each country with its particularities. Let us think that

in the future, we will continue needing vaccines, "he

explained.

Gigliotti is also a director at Vacunar, a private vaccination center, and explained that in other campaigns - those that are within the calendar - there may also be a shortage of vaccines: "It can happen, I'm not saying it's normal, but it happens. And the campaigns they must be completed, so from the vaccination centers we turn to different laboratories, which work with different platforms. The important thing is to guarantee

efficacy, safety and inform the population. "

Regarding the use of component one of the Sputnik V vaccine as a replacement for component two, he evaluated that "it is logical that the City advance with this trial. But we must

wait for the results on the immunity values

, because we remember that the coverage of Sputnik V it is very high, it is above 90%. I think that the use of the two doses of component one are worth it as long as the coverage is

equal to or greater than in the original scheme

.

"

Beyond the

lack of second doses,

which applies to the country in particular - while the shortage occurs, in general, in non-central countries - the search that drives these combination studies is to obtain similar or, even better, higher results. coverage of populations against a virus.

SC

Look also

Vaccine combination: City and Province will apply doses of Moderna starting tomorrow to complete schemes started with Sputnik V

The Government announced that the Pfizer vaccines that arrive in the country will also be used for the combination of second doses

Source: clarin

All news articles on 2021-08-06

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