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Scientific Breakthrough in the War on Cancer | Israel today

2021-08-18T18:46:14.075Z


Israeli researchers from Tel Aviv University printed a material that simulates the brain in a 3D printer, grew active cancer on it and learned new ways to fight it


A very great scientific achievement for researchers from Tel Aviv University who succeeded in combining three-dimensional printing, growing a complete and active cancerous tumor of the glioblastoma type and thanks to this, an active tumor environment can be simulated for the first time and drugs can be suppressed or prevented.

The researchers note that the printed material was based on actual samples of brain materials taken from patients straight from the operating rooms of Sourasky Hospital in Tel Aviv.

Thus, the cancerous growth in the laboratory actually resembled a real growth in a natural environment, a situation that is not possible in a normal study in which the tumor grows in two dimensions in a petri dish.

This is a significant upgrade because biologically and medically there is a huge difference between growing a petri dish and growing in its natural environment because many drugs cannot be tested in the way they have tried to treat this cancer to date. In fact until the last study there was no long-term treatment against this type of violent cancer. The results of the new study are published today in the prestigious journal Science Advances. The study was led by Prof. Ronit Sachi-Painero, who heads the Center for the Biology of Cancer Research.

"Glioblastoma is a deadly type of cancer and makes up most of the malignancies that originate in the brain," says Prof. Sci-Painero. "In a previous study, we first identified a protein called P-Selectin, which is secreted by cancer cells and causes a failure in the immune system that encourages cancer to spread. .

To this end, the research team led by Prof. Sci-Fainero together with doctoral student Lena Neufeld, created the first three-dimensional model of glioblastoma cancer, which surrounds the human brain and communicates with its environment through functioning and flowing blood vessels.

After successfully printing the tumor, Prof. Sci-Painero and colleagues showed that with the help of the model, it would be possible to quickly and efficiently predict the most appropriate treatment for a specific patient.

"We have proven that our 3D model is better suited for predicting and developing drugs in three different ways. We tested a protein that inhibited the protein we found, P-Selectin, and were able to inhibit the progression of the cancerous tumor by blocking the protein. The experiment proved some potential drugs fail the clinic On two-dimensional models, and vice versa: some cases that were considered a dizzying success in the laboratory, failed the clinical trials. "

In addition, in collaboration with Dr. Assaf Madi's Laboratory at Tel Aviv University's Department of Pathology, we genetically sequenced the cancer cells we grew in the 3D model and compared them to cancer cells grown on two-dimensional plastic and to cells we had grown from patients, and showed that the tumors were printed in 3D. Are much more similar to cancer cells in their natural environment.

The third proof was by measuring the growth rate of the tumors. If the cancer cells are injected into the animals, in some, the tumor will be dormant and in some, an active tumor will develop quickly. In the 3D printer, the rate of tumor development is consistent with the development we see in patients or model animals. "

According to Prof. Sci-Painero, this is an innovative approach that will make it possible to develop new drugs as well as discover new targets for appropriate drugs at a much faster rate than what exists today.

Source: israelhayom

All news articles on 2021-08-18

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