In recent years Lazio have made a great leap forward under Simona Inzaghi, but on Saturday the coach, who jumped at the chance to advance to champions Inter, will return to Olympico and face off against his former trainees (19:00).
For the Eagles it is a critical game, as they are 10 points away from the leading Napoli.
City rival AC Milan, who started the season almost perfectly, will host Verona (21:45).
The Rossoneri will have to make do without goalkeeper Mike Manan, Theo Hernandez, Alessandro Florenti, Davide Calabria, and Zlatan Ibrahimovic.
In another game:
Spezia will host Salarantina (16:00).