Omicron variant: Double vaccination dose shows 70 percent effectiveness

Created: 12/15/2021, 03:17 AM

By: Kim Hornickel, Tobias Utz, Lukas Rogalla, Sophia Lother

Data suggest that the booster vaccination with Biontech also protects against the omicron variant of the coronavirus.

An expert talks about the speed of spread.

• The Corona variant * Omikron has already been discovered in numerous countries around the world.

  It is considered to be significantly more infectious than other mutations of the Sars-CoV-2 coronavirus.

• Booster vaccinations seem to significantly increase protection against Omikron *.

  This is shown by initial evaluations of vaccines.

• The news situation on the Corona variant at a glance.

+++ 9:16 p.m.:

According to a South African study, two vaccinations with the corona vaccine from Biontech / Pfizer offer good protection against serious disease progression when infected with the Omikron variant. "Double dose of the Pfizer / Biontech vaccine shows 70 percent effectiveness in reducing the risk of hospitalization," said the head of the private health insurance company Discovery, Ryan Noach, on Tuesday (12/14/2021).

The study, which Discovery carried out in conjunction with the South African Council for Medical Research (SAMRC), is based on samples from 78,000 PCR tests taken between November 15 and December 7 in South Africa.

"The results are very encouraging," said SAMRC director Glenda Gray.

However, Discovery boss Noach warned that the health systems could soon be overloaded despite the very good vaccination protection.

The Omikron variant is spreading rapidly in South Africa and other countries and the number of new infections is very high.

The manufacturers Biontech / Pfizer had recently announced that two doses of their vaccine are probably not enough to protect against infection with Omikron.

According to initial study results, they only offer effective protection against the course of severe disease.

British expert suspects that Omikron will spread even faster

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A British expert sees signs that the Omikron variant of the corona virus could spread even faster than previously assumed.

First of all, it was assumed that the number of infections with the corona variant would double within two to three days, said the chief medical advisor to the British Health Authority (UKHSA), Susan Hopkins, on Tuesday in London in front of a parliamentary committee.

"At the moment, it seems that this growth rate is shorter than it is longer." She is concerned about how many people become infected every day and anticipates very difficult weeks.

The Corona variant Omikron is considered more infectious compared to other mutations.

(Symbolic photo) © Everett Collection / Imago Images

Richard Neher, head of the research group Evolution of Viruses and Bacteria at the Biozentrum of the University of Basel, warned on Twitter that conclusions should not be reached too quickly if the number of Omikron cases in a country supposedly no longer increases as quickly as it did at first.

In view of the very high number of cases, it is likely that test capacities would reach their limits and there would be delays in reporting cases, he wrote.

In an interview published by his university on Monday, Neher said that Omikron will soon have displaced other variants such as Delta across Europe.

If development continues as before, Omikron will be dominant in Europe in about two to four weeks.

The transmission rate is three times as high as with Delta.

The reason for this is that both vaccinated and unvaccinated people become infected.

Vaccinated persons were better protected against infection with the Delta variant than with Omikron.

Corona variant Omikron: Söder calls for a change of strategy

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Bavaria's Prime Minister Markus Söder has called for a uniform strategy for Germany against the Omikron variant of the corona virus. "In addition to the current Delta management, we need a uniform national Omikron strategy," said Söder on Tuesday in Munich after joint consultations between the state cabinets of Bavaria and Saxony. Söder also called for a new Prime Minister's Conference to be held soon - this year, or at least "very early" in the new year.

The omicron variant of the coronavirus causes great uncertainty because of its rapid spread.

According to Söder, there are currently 87 suspected cases and 39 confirmed infections in Bavaria.

Söder justified the need for a uniform strategy, among other things, with a different approach by the federal states.

The Bavarian Prime Minister said that people from South Africa were treated more strictly at the Munich airport than in Frankfurt am Main.

This means that the flights from South Africa will decrease in Munich, but increase in Frankfurt.

Corona variant Omikron: New details on Biontech booster

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The third corona vaccination with the vaccine from Biontech / Pfizer should provide “significant protection” from the Omikron variant.

This is suggested by the results of a new study from Sheba Medical Center and the Central Virology Laboratory of the Ministry of Health in Israel.

The booster vaccination offers protection against the omicron variant of the coronavirus, suggests a study from Israel.

(Symbol picture) © Ronny Hartmann / dpa

The protection is about four times less than against the delta variant, which is currently dominating in Germany - but much better than initially feared.

Whether the effectiveness of the booster vaccination also decreases over time is unclear and is still being investigated, said Dr.

Gili Regev-Yochay of the Jerusalem Post with.

She is the director of the Epidemiological Infectious Diseases Department at Sheba Medical Center.

Research by scientists at Oxford University in England examined the booster effect through laboratory tests with blood samples from people who had received vaccines from Astrazeneca or Biontech / Pfizer.

However, according to the study, which was published on Monday, there is still no evidence that the lower antibody levels with Omikron could lead to a higher risk of serious illness or death.

“This is important data, but it only shows part of the picture.

They only look at neutralizing antibodies after the second dose, but they don't tell us anything about cellular immunity, and it is tested, ”said vaccine scientist and one of the study's authors, Matthew Snape

Corona variant Omikron: Expert warns of “tidal wave” in Germany

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Federal Health Minister Lauterbach had announced that he would discuss such a relaxation for people with booster vaccinations with the health ministers of the federal states on Tuesday. The ministers meet in the afternoon to abolish compulsory testing across the board, some federal states have already abolished it. Teichert sees the plans with concern: The Omikron variant is on the advance and it is still unclear how well the booster vaccinations worked against it. "As long as we do not have enough data to be able to say this with certainty, we should not take any hasty steps," warned Teichert. "It would be wrong at this point in time to give up tried and tested instruments such as rapid tests." The more widely the tests are carried out, the easier it is to detect infections and trace infection chains.

The calls for tougher corona measures are getting louder. (Symbol photo) © Christian Ohde / Imago Images

The German Foundation for Patient Protection warned the federal and state health ministers against repeating old mistakes with this step: "With the Omikron variant, a tidal wave is rolling towards Germany," said board member Eugen Brysch to the Funke newspapers. "That is why the health ministers must not decide to relax." Giving political gifts before Christmas would be punished in January. “There was exactly the same mistake last year. That mustn't be repeated now, ”warned Brysch. The President of the German District Association, on the other hand, stood behind Lauterbach's project: "It is easy to understand why the test is no longer required for those who have been boosted," said District President Reinhard Sager of the Funke newspapers. The protection is much more effective with the third vaccination.

Corona summit: Lower Saxony's health minister sees "blazingly fast" Omikron spread

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According to the Lower Saxony Minister of Health, the Omikron variant of the corona virus will also spread quickly in Germany.

"We are assuming [...] that we will basically have Omikron as the predominant variant in Germany at the end of January, beginning of February," said Daniela Behrens (SPD *) on Tuesday morning in the health committee of the state parliament in Hanover.

The variant spreads "very quickly".

In the afternoon, Behrens consults with her colleagues at the Corona summit.

Behrens emphasized that the vaccines used also worked against Omikron.

However, it is still unclear whether the intensity of two vaccinations is sufficient for the immune response.

The minister also stated that the Christmas rest planned in Lower Saxony was primarily intended to contain the Omikron variant.

The state government is tightening the corona rules from Christmas Eve until January 2 - regardless of the then current indicators on the corona situation.

The country is taking a different path.

Corona summit: Expert advice advises measures for the first time

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On Tuesday, a council of experts from the federal government will advise on further corona measures for the first time. Karl Lauterbach, the new Federal Minister of Health, wants to involve the committee of experts from science more closely in decisions in the future. "Policy in the pandemic needs scientific advice," Lauterbach told the Rheinische Post.

The new Federal Minister of Health wants to implement his new line at an expert meeting on Tuesday (December 14th, 2021).

At the first meeting of the Federal Government's new Expert Council, politicians, doctors and scientists from other fields will discuss.

And Karl Lauterbach promises to take the opinion of the experts first.

"The exchange with my former colleagues will be the basis of my crisis management and the entire federal government," said Lauterbach.

Danger from Corona variant Omikron: Expiry date required for vaccination certificates

Update from Tuesday, December

14th, 2021, 6.30 a.m.: Because of the omicron variant of the coronavirus, which is still spreading, the Green * health politician Janosch Dahmen is calling for extensive preparation.

"Omikron is not yet reflected in the incidence rising again tomorrow, but we have to take precautions today," said Dahmen of the Rheinische Post.

The Green politician called for three concrete steps: The interval between the second and third vaccination must be shortened, an expiry date for the vaccination certificates and a new entry regulation are necessary.

At the upcoming Corona summit of the health ministers on Tuesday (December 14th, 2021), new resolutions are expected to increase the vaccination rate again in view of Omikron.

Other countries in the European Union are also adopting stricter measures in view of the rapid spread of the virus mutation.

In Norway, the government has therefore tightened the corona measures in the country around a week and a half before Christmas.

Restaurants and hotels will no longer be allowed to serve alcohol for the next four weeks.

There are also stricter rules for public events, in cultural life and for organized leisure activities.

Corona variant Omikron: "Run" on vaccination centers in Great Britain

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Even before it became known that “at least one patient” had died in Great Britain as a result of a corona infection with the omicron variant, it was determined that the mutation was spreading at “phenomenal speed”.

"We have never seen anything like it," said Health Minister Sajid Javid on TV broadcaster Sky News.

Prime Minister Boris Johnson has already appealed to the population several times to be boosted.

His appeals now seem to be working.

On Monday (December 13th, 2021) there was a "run" on vaccination centers and pharmacies in Great Britain *.

Before 9 a.m. in the morning, more than 110,000 people had been vaccinated against the corona virus for the third time.

+++ 1 p.m.:

In Great Britain there is the first death related to a corona infection of the Omicron variant. Prime Minister Boris Johnson * announced this on Monday (December 13th, 2021). "Sadly, Omikron leads to hospitalizations and unfortunately it has been confirmed that at least one patient has died from Omikron," said Johnson during a visit to a vaccination clinic in London.

+++ 12.45 p.m.:

The vaccine from Biontech / Pfizer * apparently has a weaker effect against the circulating omicron variant of the corona virus. This is shown by a study that also examined the Astrazeneca * vaccine, for example. The study was based on population data from Great Britain. According to the scientists, however, the benefits of a booster vaccination became apparent. As a result, the vaccination protection has been significantly increased.

Biontech boss Ugur Sahin recently emphasized that a third vaccination would make sense in view of Omikron.

"With regard to Omikron, two doses are not yet a completed vaccination with sufficient protection," he told the news magazine Spiegel.

"If Omikron continues to expand, it would make scientific sense to offer a booster after just three months," said Sahin in an interview.

Omikron: Lauterbach reveals plans to avert the new corona wave

First report from Monday, December 13th, 2021, 9:30 a.m .:

Berlin - The Corona variant Omikron is now also spreading in Germany - and at a dramatic time. Because: Even before the variant appeared, the nationwide incidence rose steadily. The number of cases of corona infections in Germany * has been high for weeks, the incidence at times above 400.

As reported by the Robert Koch Institute, the predominant variant in Germany is still the delta variant. * In calendar week 48, over 99 percent of citizens were still infected with this variant.

Less than one percent became infected with the alpha variant * and Omikron.

But the research results so far on the new mutant indicate that these numbers could soon increase significantly, and are getting experts from all over the world.

Corona variant Omikron: Model shows what makes the mutant so dangerous

Accordingly, the Corona variant Omikron avoids vaccination protection *.

Virologist Sandra Ciesek already urged on Twitter that "the development of a vaccine adapted to Omikron makes sense".

At first glance, the research results on the course of the mutant seem like positive news.

Because the variant could be more contagious, but not more deadly.

But Federal Health Minister Karl Lauterbach * saw himself forced on Twitter to destroy even this faint hope.

Corona mutant Omikron: Karl Lauterbach shares worrying model

In his tweet, Lauterbach shared a model calculation by biologist Gasperowicz from the University of Calgary in Canada. The model shows the case numbers of three possible variants. One with quick transferability and a normal course of the disease, the other with high transferability that is comparatively “mild”. The deaths from the latter are just as high over time. The lowest number of deaths is found in the variant whose transferability is rather low and whose fatality is twice as high.

Lauterbach commented on the model with the words: “Here you can see again in the model calculation why Corona variants, which are much more contagious, kill significantly more people than more deadly ones that do not spread quickly.

Severe course kills linearly, high contagion kills exponentially.

That is where the danger from Omikron lies ”.

Lauterbach on Corona variant Omikron: "Booster vaccination incredibly valuable"

The new health minister also spoke about this. At Anne Will * on ARD *, he clearly relies on boosting. Because with the third vaccination, the protection increases again to 75 percent. The people who became infected despite the corona vaccination would usually not get seriously ill. "The booster vaccination is therefore incredibly valuable because we can both end the delta wave and avert the omicron wave," says Lauterbach.

Therefore, the Federal Minister of Health wants to make booster vaccinations one of his priorities in the next few months.

It is important to press down the delta wave now.

Lauterbach expects that the first "anti-omicron vaccines" will be available from April or May.

"If we have broken the delta wave by then and have pushed the omicron wave in front of us with the booster vaccination, then we can get through quite well," says Lauterbach, ultimately giving hope.

(slo / tu / kh / lrg with dpa / AFP)