"Not a substitute for a vaccine but another tool in the toolbox": Corona drugs will land in Israel today
Pfizer's pills will arrive in Israel and Prof. Yosef Karko, who headed the Israeli drug research team at the Merck company, clarifies that it is intended for mild or moderate patients in risk groups as well as for infected vaccines and emphasizes that "the vaccine is most important."
Everything you need to know about Corona drugs
Meirav Cohen
30/12/2021
Thursday, December 30, 2021, 6:30 p.m.
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In the video: Pfizer CEO refers to the company's new drug for Corona (Photo: Reuters)
Pfizer's drug against the corona virus, 'Paxlobid', is expected to land today (Thursday) at Ben Gurion Airport. In a few weeks, the company's drug, called MSD, will also arrive. Both drugs have been approved for use by the US Food and Drug Administration (FDA) and by the Ministry of health.
Professor Joseph Karako, director of the unit of clinical Pharmacology at Hadassah Ein Kerem hospital in Jerusalem, and headed a team of Israeli study of drug origins of MSD and development of the vaccine Israel coming from, do order the drugs, dosages and prescriptions.
"We learned that vaccines it The most important thing, "explains Professor Karko." But we are in the fifth wave, we know that they are not everything.
We want to increase our toolbox.
To date, we have dealt with viral diseases with the help of hot soup for a few days in bed, so these drugs can be a change of perception not only for Corona, but for all viral diseases. "
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Prof. Yosef Karko (Photo: Official Website, Section 27A of the Copyright Law)
According to the companies, the drugs against corona are antiviral, and they prevent the virus from replicating and becoming a more serious disease.
The drugs are intended for mild or moderate patients and provided they have a risk factor for a serious illness, and not for the entire population.
"Until today we treated the critically ill when they came to hospitals, but when the disease becomes severe, it is no longer just a viral disease, but the general system becomes ill. Today we understand that treating only the critically ill is not enough, and that they were not born critically ill, and we want to catch them. When they are light. "
Both drugs have a common denominator - they are unrelated or targeted to certain mutations, since they are not protein-based, so their effectiveness will be good even if the corona develops into other strains.
In addition, both are given in pills a few days after the onset of symptoms, so it is important to go and get tested immediately upon their onset.
What is the difference between the drugs?
Pfizerloxide
has been found to be 89% effective in preventing hospitalization and mortality, and can also be given to children over the age of 12. Professor Carco also explains the drug's limitations: "In addition, it should not be given to people with significant kidney or liver disease. It is problematic because these are the people who are at risk and need the drug the most. The family doctor should know whether to ban it completely or reduce the dose."
Soup MSD
It began with experiments in Israel, so some Israelis have already received it.
Its efficiency percentage is only 30%, but the State of Israel is purchasing it to increase the supply and give it to those patients for whom Pfizer's medicine is not good.
Karko explains: "This drug has almost no side effects and is also intended for people with kidney failure, but it also has limitations - it is not intended for children, but only over the age of 18. The reason is that even during the experiments on animals it was found that the drug actually harms "We have only seen it in young animals - puppies. Therefore it is not given to children, because their bones are still growing. In addition, it is not intended for pregnant women and the attending physician should make sure that there is no intention to get pregnant during treatment."
"Faxlobid" (Photo: Reuters)
Who is the drug for?
"The drug is intended for patients in risk groups. The main risk factor in corona is overweight and therefore priority will be given to overweight people. Other populations are the elderly over 60, diabetics and patients with lung and kidney disease. The drugs should be given up to five days after symptoms appear. "
Karko clarifies: "No one should think that it is a substitute for a vaccine, the vaccine is the most important and the first and foremost tool. If you have been vaccinated and infected - there is a solution."
Do you think unvaccinated people should be given priority because they are in a risk group?
"The studies were conducted in unvaccinated people because they wanted to achieve the fastest result, but an unvaccinated person is not considered a at-risk population," Karko states, concluding with cautious optimism: "Great and therefore the people who are with him in the same house will not be infected. It may be that this is how we will reduce the infection, but these are preliminary things and are being tested."
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