More than 1.18 million people were infected in the fifth wave of the epidemic in Hong Kong. Tsang Tak-yin, Chairman of the Task Force on Clinical Infectious Disease Treatment of the Hospital Authority and Medical Director of the Infectious Disease Center, said on Friday (22nd) that the authorities have purchased the first batch of more than 190 doses of AstraZeneca preventive medicine The new crown antibody drug Evusheld will be used for chronically ill patients with poor immunity.
The two oral drugs purchased earlier, Pfizer's Paxlovid and Merck's Molnupiravir, have achieved remarkable results, reducing the mortality rate by 80% and 40% respectively, and have side effects. slight.
Zeng Dexian urged patients, especially the elderly and high-risk individuals who have been diagnosed, to seek medical treatment as soon as possible so that they can receive drug treatment in a timely manner.
AstraZeneca's preventive new crown antibody drug Evusheld.
(AstraZeneca picture)
First batch of 190 doses of AstraZeneca's preventive antibody drug
Zeng Dexian said that the authorities have purchased 190 doses of AstraZeneca's preventive antibody drugs, which are only the first batch, so there are not many, and they are mainly used for long-term patients with poor immunity, and will continue to discuss subsequent purchases with drug manufacturers later. matter.
Clinical data in Hong Kong Pfizer, Merck & Co. drop mortality rates by 80% and 40%
As for the two oral drugs currently available in Hong Kong, Tsang Dexian pointed out that according to the New England Journal of Medicine, taking Pfizer's Paxlovid within three days of onset can reduce the risk of hospitalization and death by 89%. %, and taking it within 5 days also reached 88%, and the viral load was reduced by more than 80%; taking Molnupiravir from Merck Pharmaceuticals within 5 days of the onset, the risk of hospital and death was reduced by 30%, and the viral load was reduced by 30%. volume decreased by more than 60%.
According to data from Princess Margaret Hospital and the Hong Kong Center for Infection Control, 5,356 patients did not take Paxlovide, of which 314 patients died, or about 5.9%; 888 patients took Paxlovide, only 11 The mortality rate was only 1.2%. It can be seen that the mortality rate of Paxlovide was 80% lower than the mortality rate of those who did not take the drug.
In addition, 5,338 patients did not take monapiravir, of which 429 patients died, or about 8% of the deaths; 1,513 patients took monapiravir, only 69 patients died, or only 4.6% of the deaths, It can be seen that the mortality rate of taking monapiravir is 40% lower than that of those who did not take the drug.
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Some patients did not receive oral medication due to the "golden period" of more than five days
截至4月19日為止，兩款口服藥已於公立醫院、指定診所、安老院舍、社區隔離設施等地派發使用，累計處方接近28,000名患者。其中三個聯網指定診所約60%的60歲以上患者獲發口服藥，少於10%年齡低於60歲患者獲發口服藥。
Forty-nine percent of inpatients in Princess Margaret Hospital received oral medication, while 83 percent of patients in residential care homes received oral medication.
As for private clinics, there is no exact data, but the number of prescriptions is only in single digits.
Zeng Dexian said that most of the patients who did not receive oral medicines missed the "golden period" of treatment because their symptoms lasted for more than five days, so they did not receive medicines.
He pointed out that oral medication can effectively improve the patient's condition, but some patients think that their symptoms are mild and do not seek medical treatment.
He believes that this move will increase the risk of hospitalization and death, and appeals to patients, especially the diagnosed elderly and high-risk people, to seek medical treatment as soon as possible so that they can get medical treatment as soon as possible.
Zeng Dexian, Chairman of the Task Force on Clinical Infectious Disease Treatment of the Hospital Authority and Director of the Infectious Disease Center, said that the authorities have purchased the first batch of more than 190 doses of AstraZeneca, which will be used for patients with poor immunity, and will continue to discuss the follow-up purchase with the pharmaceutical manufacturer later. .
(File photo / Photo by Luo Junhao)
Mild side effects can block virus replication
Zeng Dexian also pointed out that although oral medication can cause adverse reactions, including diarrhea, vomiting and other symptoms.
However, the duration of taking the medicine is only five days, and the side effects are mild and the sensitivity is less.
Only a small number of patients stopped taking the drug due to side effects, and no serious side effects have occurred after taking the drug for the time being. Therefore, it is believed that both oral drugs are very safe.
He pointed out that both oral drugs can stop the virus from replicating in the human body.
In addition, Hong Kong currently has sufficient stocks of oral medicines to cope with the sixth wave.
The authorities will closely monitor the situation and repurchase if necessary. We believe that the medicines will arrive in Hong Kong quickly.
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