Hong Kong recorded its first imported case of monkeypox on Monday (5th), causing the public to be concerned about when the monkeypox vaccine will arrive in Hong Kong.
According to Liu Yulong, chairman of the Scientific Committee on Vaccine Preventable Diseases, earlier revealed to the media that the modified vaccinia virus vaccine (Modified Vaccinia Ankara) purchased by the Hong Kong government.
The currently circulating monkeypox virus has mutated, and some members of the public are worried that the effectiveness of the vaccines purchased may be broken.
The University of Science and Technology and the University of Melbourne, Australia, announced a joint study. It is expected that the current smallpox vaccine can still induce a strong immune response to the monkeypox virus in humans, including the vaccine purchased by the Hong Kong government.
The findings have been published in the international scientific journal Viruses.
Hong Kong recorded its first imported case of monkeypox on Monday (5th), causing the public to be concerned about when the vaccine for waiting for pox will arrive in Hong Kong.
A 1997 photo provided by the U.S. Centers for Disease Control and Prevention (CDC) shows a monkeypox patient showing a rash on the back of his hand.
(AP)
The monkeypox virus is spreading rapidly, and the first imported case was recorded in Hong Kong this week, which makes people worry about whether the monkeypox virus will spread to Hong Kong.
The government has always stated that there will be vaccines coming to Hong Kong within this month, but the number of doses and which vaccine to buy has not been announced. In addition, the currently circulating monkeypox virus has mutated, which makes people worry about the vaccines purchased by the Hong Kong government. Effectiveness against monkeypox virus.
According to Liu Yulong, chairman of the Scientific Committee on Vaccine Preventable Diseases, the government purchased a modified vaccinia virus vaccine (Modified Vaccinia Ankara), which is a highly live attenuated vaccine.
▼On September 6, the patient of the first imported monkeypox case stayed in a hotel in Sai Ying Pun▼
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The University of Science and Technology and the University of Melbourne, Australia, conducted joint research on the currently available smallpox vaccine MVA-BN (that is, the vaccine purchased by the Hong Kong government) and the ACAM2000 vaccine.
The research team conducted genomic analysis within weeks of the emergence of the new monkeypox virus strain to see whether the new genetic mutation observed in this year's monkeypox outbreak could affect the immune response to the monkeypox virus produced by the vaccine.
The picture shows that the vaccine developed by the vaccinia virus produces antibodies that attack two protein examples, and the 2022 monkeypox virus does not have any new mutations.
(Provided by HKUST)
Using genomic and immunological data, the research team compared the genetic similarities and differences between the vaccinia virus and the new monkeypox virus, especially the so-called "antigenic epitopes" recognized by T cells and neutralizing antibodies induced by the vaccine part of the protein.
The research team found that although the current virus strain has 50 single base pair variations (SNPs) compared with the monkeypox virus strains collected in the past three years, its protein part includes the proteins of eight "epitopes" that elicit neutralizing antibodies. , there is a high genetic similarity of 96% with the current reference sequence of the new monkeypox virus strain, so it is expected that the current smallpox vaccine can still induce a strong immune response to the monkeypox virus in humans.
The research is led by Ahmed Abdul QUADEER (left), Research Assistant Professor, Department of Electronic and Computer Engineering, HKUST, and Professor Matthew MCKAY, University of Melbourne, Australia.
(Provided by HKUST)
Ahmed Abdul QUADEER, research assistant professor in HKUST's Department of Electrical and Computer Engineering, who led the study, said the results could reduce anxiety about the new monkeypox virus, and it is expected that the immune response generated by the smallpox vaccine will continue to be effective against the new monkeypox virus, as The same is true for the monkeypox virus that appeared earlier.
However, Professor Matthew MCKAY of the University of Melbourne, Australia, added that although genetic sequencing and immunological data have provided evidence to expect a strong immune response, we still need clinical studies to determine the exact efficacy of these vaccines against the new monkeypox virus.
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