For Mauricio Pochettino's first on his bench, Paris Saint-Germain could not do better than a draw (1-1) at Geoffroy-Guichard on Wednesday night.
Kean responded to Hamouma's opener.
At Groupama Stadium, Lyon dominated Lens (3-2) with a double from Depay and take sole control of Ligue 1, three points ahead of Paris and Lille, beaten at home by Angers (1-2).
Handsome winner of Montpellier (3-1) with goals from Radonjic, Payet and Germain at the Vélodrome, Marseille remains 5th five points from the podium but with two late matches to play.
In the last match of the evening, Reims and Dijon parted back to back (0-0).
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League 1 standings