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Pfas alter blood clotting

2020-01-24T13:10:31.899Z

An Italian research has found that these pollutants can activate platelets, making them more susceptible to clotting and predisposing to an increased cardiovascular risk. (HANDLE)



The link between Pfas pollution, the chemicals that may be present in paints, drugs and medical devices, and cardiovascular diseases has been identified. An Italian research has found that these pollutants can activate platelets, making them more susceptible to clotting and predisposing to an increased cardiovascular risk. The research is from the University of Padua under the guidance of Carlo Foresta, an endocrinology professor, with the groups of Luca De Toni and Andrea Di Nisio.

The research, published in the International Journal of Molecular Sciences, was born from the observations reported both in international studies and by the Veneto Regional Epidemiological Service which indicate an increase in the cardiovascular risk associated with Pfas pollution, the perfluorinated compounds that are used to make resistant many products with fats and water, from fabrics to coatings for food containers. In particular, the researchers showed that one of these substances, Pfoa (perfluorooctanoic acid), the main environmental pollutant in the Veneto region, "would be able to activate the platelets, making them more susceptible to coagulation, even in normal conditions, predisposing to an increase in cardiovascular risk, "explains Foresta.

The result was obtained first in vitro and then confirmed, in collaboration with Paolo Simioni of the University of Padua, thanks to tests on 78 people with different levels of exposure to Pfas. The tests "confirmed signs of increased platelet activation with a consequent increase in their propensity to aggregate", notes Foresta. "These data - he adds - could explain the epidemiological observation between Pfas and cardiovascular pathologies, especially if there are other known risk factors for these pathologies, such as diabetes, obesity, smoking and alcohol".

Source: ansa

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