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Covid, new antiviral works in hamsters

2022-02-16T09:19:47.385Z


Works against Covid-19, the new antiviral PF-332: tested in hamsters against the Beta and Delta variants, it is able to block the infection and reduce the risk of contagion (ANSA)


It works against Covid-19, the new antiviral called PF-07321332 (PF-332): tested in hamsters against the Beta and Delta variants, it is able to block the infection and reduce the risk of contagion.

This is demonstrated by the results published in Nature Communications by a team coordinated by Johan Neyts of the Catholic University of Leuven in Belgium.

The new antiviral, developed by Pfizer, is a potent inhibitor of the protease enzyme that the SarsCoV2 virus uses to replicate.

The drug, which can be administered orally, was tested in vitro and on animal models against three variants of the virus: Alpha, Beta and Delta.

First, its antiviral efficacy against the Alpha variant has been demonstrated in tests conducted on mammalian cells and in a model that reproduces the human respiratory epithelium in a test tube.

Subsequently, the drug was tested on small groups of hamsters: those infected intranasally with the Beta or Delta variant did not develop symptoms of the disease after four days of treatment.

The researchers also infected six other hamsters with the Delta variant and then locked them in a cage with six other healthy hamsters: in this way they observed that animals treated with PF-332 for three days do not transmit the infection.

According to the authors of the study, these results demonstrate that PF-332 could become the ideal drug to combine with others (such as molnupiravir, favipiravir or an oral version of remdesvir) in order to obtain maximum antiviral potency while reducing the risk of developing new ones. resistant variants.

Source: ansa

All tech articles on 2022-02-16

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