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Mice rejuvenated without the risk of tumors

2022-03-09T11:04:37.169Z


Rejuvenates without causing side effects, the anti-aging therapy that erases the signs of aging by reprogramming the cells: it was administered to mice from middle age to old age (ANSA)


Going back young without paying a pledge: a dream that could come true, thanks to an innovative anti-aging therapy that erases the signs of aging by reprogramming the cells.

Given to mice from middle age through old age, it rejuvenated them without causing tumors or other health problems.

This is demonstrated by the study published in the journal Nature Aging by the Salk Institute in California in collaboration with the Genentech company of the Roche group.

"We are thrilled to be able to use this lifelong approach to slow aging in animals - the technique is safe and effective in mice," says Juan Carlos Izpisua Belmonte of the Salk Institute.

"In addition to addressing age-related diseases, this approach can provide the biomedical community with a new tool to restore tissue and organism health by improving cell function and resilience in various pathological situations, such as neurodegenerative diseases."

To turn back the hands of the biological clock, the researchers used a cocktail of four molecules (Oct4, Sox2, Klf4 and cMyc, better known as 'Yamanaka factors') capable of reprogramming the epigenetics of cells, or the modifications chemicals (inheritable or acquired as a result of the environment or lifestyle) that coat the DNA by regulating its expression.

In 2016 they had already experimented with the elixir of youth in mice suffering from premature aging, while more recently they had shown that the mix is ​​able to accelerate the regeneration of muscles in young mice.

In light of these early experiments, other research groups had tried the same approach to improve the function of tissues and organs such as the heart, brain and optic nerve.

Nobody,

To do this, the Salk Institute researchers administered the cocktail of molecules to healthy 15-month-to-22-month-old mice (the equivalent of a therapy taken from 50 to 70 years of age in humans) and to 12-month-to-12-month-old mice. at 22 months (35 to 70 years in humans), while a third group of 25-month-old mice (equal to 80 years in humans) was treated for one month.

"We wanted to verify that using this approach over a longer period of time was safe," says Pradeep Reddy, researcher at the Salk Institute.

"In fact, we did not find any negative effects on the health, behavior or body weight of these animals."

At the end of the therapy, in fact, no mice showed alterations of the blood cells, neurological anomalies or tumors.

Older mice treated for one month showed no signs of rejuvenation, while mice treated for seven or ten months improved, both in skin and kidney cell epigenetics, and in 'spy' molecules. metabolism present in the blood.

The effects of the elixir of youth, however, are not noticeable in the middle of the treatment period, but only at the end.

This could indicate that Yamanaka's factors not only stop the hands of the biological clock, but are able to turn them back.












Source: ansa

All tech articles on 2022-03-09

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